CAJ | 학술논문

目的观察中西医结合方法治疗妊娠剧吐的临床疗效及其对血清胃动素影响.方法选妊娠早期妊娠剧吐患者60例,随机分为对照组和治疗组各30例;同期正常妊娠早期无呕吐者30例为正常组.对照组采用西医补液支持治疗;治疗组在西医补液支持治疗同时口服中药孕吐方,疗程6天.于治疗前后检测血清胃动素和人绒毛膜促性腺激素(β-HCG)值,并随访2周.结果治疗组及对照组的治愈率和复发率分别为73.3%(22/30)、20.0%(5/25)和56.7%(17/30)、50.0%(10/20),治疗组的治愈率高,而复发率低于对照组(P<0.05);血β-HCG治疗前后3组比较差异均无统计学意义(P>0.05);血清胃动素(ng/L)治疗前正常组、治疗组和对照组分别为145.35±30.12,67.15±15.94,70.28±13.56,治疗组、对照组与正常组比较差异有统计学意义(P<0.05);治疗后治疗组与对照组分别为151.50±54.84,103.28±38.31,较治疗前均有增加(P<0.05),治疗组较对照组增加更明显(P<0.05).结论妊娠剧吐的发生与孕妇血清胃动素降低有关,中西医结合治疗妊娠剧吐疗效显著,可能与其增加血清胃动素、促进胃蠕动有关.
목적 관찰중서의결합방법치료임신극토적림상료효급기대혈청위동소영향.방법 선임신조기임신극토환자60례,수궤분위대조조화치료조각30례;동기정상임신조기무구토자30례위정상조.대조조채용서의보액지지치료;치료조재서의보액지지치료동시구복중약잉토방,료정6천.우치료전후검측혈청위동소화인융모막촉성선격소(β-HCG)치,병수방2주.결과 치료조급대조조적치유솔화복발솔분별위73.3%(22/30)、20.0%(5/25)화56.7%(17/30)、50.0%(10/20),치료조적치유솔고,이복발솔저우대조조(P<0.05);혈β-HCG치료전후3조비교차이균무통계학의의(P>0.05);혈청위동소(ng/L)치료전정상조、치료조화대조조분별위145.35±30.12,67.15±15.94,70.28±13.56,치료조、대조조여정상조비교차이유통계학의의(P<0.05);치료후치료조여대조조분별위151.50±54.84,103.28±38.31,교치료전균유증가(P<0.05),치료조교대조조증가경명현(P<0.05).결론 임신극토적발생여잉부혈청위동소강저유관,중서의결합치료임신극토료효현저,가능여기증가혈청위동소、촉진위연동유관.
Objective To study the clinical therapeutic effect of integrative Chinese and Western medicine on patients with hyperemisis gravidarum(HG)and its influence on serum level of motilin(MOT).Methods Sixty patients with HG were randomized equally into two groups,the treated group and the control group.They all received the Western medical supportive treatment mainly by fluid infusion,but for patients in the treated group,Chinese herbal medicine,the Yuntu recipe was given orally in combination.The course of treatment was 6 days.Besides,a group of 30 women with regular pregnancy was set up for normal control.Serum levels of MOT and β-HCG were measured before and after treatment.And patients were followed up for 2 weeks.Results The curative rate and the relapse rate was 73.3%(22/30)and 16.7%(5/25)in the treated group;56.7%(17/30)and 33.3%(10/20)in the control group respectively,the curative rate was significantly higher and the relapse rate was significantly lower in the treated group than those in the control group(P>0.05).Blood β-HCG levels in the two HG groups were similar to that of the normal control,and changed insignificantly after treatment(P>0.05),while serum level of MOT in them were 67.15±15.94 ng/L and 70.28±13.56 ng/L respectively before treatment,significantly lowers than that of the normal control(145.35±30.12 ng/L,P<0.05),but it increased significantly after treatment in the treated and the control groups(P<0.05),being 151.50±54.84 ng/L vs 103.28±38.31 ng/L and the increasing in the treated group was more significant than that in the control group(P<0.05).Conclusion The occurence of HG is correlated with the lowering of serum MOT level.Integrative medical treatment is effective in treating HG by way of increasing the serum level of MOT and promoting the peristalsis of stomach.