CAJ | 학술논문

色素上皮衍生因子(PEDF)是一种高效、天然的血管增生抑制剂,具有神经营养保护、调节血管通透性和高效抑制血管生成等作用.近年来有研究表明,PEDF的减少与糖尿病肾病(DN)有密切关系,PEDF可抑制转化生长因子-β1(TGF-β1)和结缔组织生长因子(CTGF)的表达,抑制细胞外基质(ECM)的聚积,提示其具有抗纤维化活性,同时可通过调节肾脏脉管系统发展和维持肾自身稳态来发挥对DN的保护作用.PEDF可抑制DN的发生、发展,可能成为DN治疗的一种新方向.
색소상피연생인자(PEDF)시일충고효、천연적혈관증생억제제,구유신경영양보호、조절혈관통투성화고효억제혈관생성등작용.근년래유연구표명,PEDF적감소여당뇨병신병(DN)유밀절관계,PEDF가억제전화생장인자-β1(TGF-β1)화결체조직생장인자(CTGF)적표체,억제세포외기질(ECM)적취적,제시기구유항섬유화활성,동시가통과조절신장맥관계통발전화유지신자신은태래발휘대DN적보호작용.PEDF가억제DN적발생、발전,가능성위DN치료적일충신방향.
Pigment epithelium-derived factor(PEDF)is an efficient natural angiogenic inhibitor that can protect neuronal nutrition,regulate vascular permeability and antiangiogenie activity.Recent studies show that the decrease of PEDF levels may be closely involved in diabetic nephmpathy(DN).PEDF inhibits the expression of TGF-β1 and CTGF,and suppresses the production of ECM protein in diabetic kidney,suggesting it has antifibrogenic activity.Meanwhile,PEDF phys a role in regulating the development of renal vasculature and maintenance of renal homeostasis,and may be responsible for its salutary effect in DN.PEDF can inhibit the occurrence and development of DN,and may become a new target for the treatment of DN.