CAJ | 학술논문

目的采用基于体素形态学测量(VBM)和行为学相结合的方法,检测全脑容积及情绪记忆成绩,以探讨情绪记忆增强效应相关脑区形态学特点.方法 32名健康年轻人参加实验.试验过程包括情绪记忆行为学检测和磁共振扫描两个阶段,其中行为学检测包括记忆编码和再认,并记录行为学成绩.利用3.0T磁共振采集伞脑容积数据.采用VBM5对全脑容积进行分割,获得脑灰质、脑白质和脑脊液容积.运用SPM5和SPSS13.0统计软件包进行相关统计分析.结果情绪图片再认正确率较中性图片正确率高(t=5.08,P＜0.01),增强效应明显(△Pr=0.12±0.01)；情绪记忆增强效应主要相关脑区包括双侧杏仁核、额叶背外侧、额中回、前额叶背内侧、梭状回、右侧海马旁回、左侧眶回、中扣带回,并与双侧杏仁核容积率显著相关(左:r=0.564,P＜0.01,右:r=0.541,P＜0.01).结论从脑形态结构水平证实了杏仁核等相关脑区是参与情绪记忆的重要脑结构,进一步扩展了功能成像的相关研究结果.
목적 채용기우체소형태학측량(VBM)화행위학상결합적방법,검측전뇌용적급정서기억성적,이탐토정서기억증강효응상관뇌구형태학특점.방법 32명건강년경인삼가실험.시험과정포괄정서기억행위학검측화자공진소묘량개계단,기중행위학검측포괄기억편마화재인,병기록행위학성적.이용3.0T자공진채집산뇌용적수거.채용VBM5대전뇌용적진행분할,획득뇌회질、뇌백질화뇌척액용적.운용SPM5화SPSS13.0통계연건포진행상관통계분석.결과 정서도편재인정학솔교중성도편정학솔고(t=5.08,P＜0.01),증강효응명현(△Pr=0.12±0.01)；정서기억증강효응주요상관뇌구포괄쌍측행인핵、액협배외측、액중회、전액협배내측、사상회、우측해마방회、좌측광회、중구대회,병여쌍측행인핵용적솔현저상관(좌:r=0.564,P＜0.01,우:r=0.541,P＜0.01).결론 종뇌형태결구수평증실료행인핵등상관뇌구시삼여정서기억적중요뇌결구,진일보확전료공능성상적상관연구결과.
Objective The brain volume and behavioral performance of emotional memory were measured by combining voxel-hased morphometry (VBM) and behavior to explore the morphological characters of brain regions related to the emotional enhancement effect of memory.Methods A total of 32 healthy young subjects participated in the study.The experimental processes included MR scan and behavioral performance of emotional memory the latter of which involved two phases-encoding and retrieval.Behavioral performance was recorded and the whole-brain 3D MRI data were acquired via 3.0T MR.3D MRI data were segmented by VBM5,and the wholebrain volumes of gray matter,white matter and CSF were produced.SPM5 and SPSS13.0 were used for statistical analysis of the 3D MRI data and behavioral data,respectively.Results Retrieval accuracy of the emotional pictures was higher than that of the neutral pictures ( t =5.08,P＜0.001 ),the emotional enhancement effect was significant ( Δ Pr =0.12 ± 0.01 ).Brain regions related to emotional enhancement effect included bilateral amygdala,dorsolateral prefrontal cortex,middle frontal gyrus,dorsomedial prefrontal cortex,fusiform gyms,right parahippocampus,left orbitofrontal cortex and middle cingulate gyms.Volume ratio of bilateral amygdala were related to emotion enhancement effect evidently (left:r=0.564,P＜0.01 ; right:r=0.541,P＜0.01 ).Conclusion This study morphologically confirms that brain regions,such as amygdale and prefrontal cortex,are critical structures for the enhancement of emotional memory,and further extends the findings of previous functional imaging studies.