CAJ | 학술논문

血管内皮细胞通透性的变化与人类的许多疾病有关,如动脉粥样硬化、高血压、中风、炎症反应、肿瘤、糖尿病引起的视网膜病变和黄斑水肿等.剪切力是作用于血管内皮细胞的主要力学因素并对血管内皮细胞通透性起重要作用.Rho GTP酶家族是细胞信号转导通路中的一类重要蛋白,参与血管内皮细胞通透性的调控.研究表明,Rho GTP酶在介导剪切力引起血管内皮细胞通透性变化的过程中起重要的信号传导作用.就剪切力对血管内皮细胞通透性的影响以及Rho GTP酶在其分子机制上的作用进行综述.
혈관내피세포통투성적변화여인류적허다질병유관,여동맥죽양경화、고혈압、중풍、염증반응、종류、당뇨병인기적시망막병변화황반수종등.전절력시작용우혈관내피세포적주요역학인소병대혈관내피세포통투성기중요작용.Rho GTP매가족시세포신호전도통로중적일류중요단백,삼여혈관내피세포통투성적조공.연구표명,Rho GTP매재개도전절력인기혈관내피세포통투성변화적과정중기중요적신호전도작용.취전절력대혈관내피세포통투성적영향이급Rho GTP매재기분자궤제상적작용진행종술.
Dysfunctions of vascular endothelial permeability are related to a number of human diseases such as atherosclerosis, high blood pressure, stroke, inflammation, cancer, diabetes-induced retinopathy, macular edema and so on. Shear stress is an important mechanical force that affects vascular endothelial cells. It plays a particular role in permeability regulation. Rho GTPases is a family of small G proteins which act as cell signal molecules. They are assumed to mediate the regulation of the permeability of vascular endothelial cells. In this paper review is given on how shear stress regulates the permeability of vascular endothehal cells as well as the in-fluence of Rho GTPases on the role in molecular mechanism. It is suggested that shear stress-regulated vascular endothelial permeability is mediated by Rho GTPases.