中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
1期
1-4
,共4页
刘海行%赵冬%王薇%秦兰萍%刘军%孙佳艺%王淼%李岩%齐玥%刘静
劉海行%趙鼕%王薇%秦蘭萍%劉軍%孫佳藝%王淼%李巖%齊玥%劉靜
류해행%조동%왕미%진란평%류군%손가예%왕묘%리암%제모%류정
糖尿病%高敏C反应蛋白%前瞻性研究
糖尿病%高敏C反應蛋白%前瞻性研究
당뇨병%고민C반응단백%전첨성연구
Diabetes%High-sensitivity C-reactive protein%Prospective study
目的 研究高敏C反应蛋白(hs-CRP)与5年糖尿病发病风险的关系.方法 研究对象来源于"中国多省市心血管病前瞻性队列研究"中的北京大学社区队列.2002年对该队列45～74岁1541人进行心血管病危险因素调查和hs-CRP水平测定,2007年进行危险因素复查,对两次资料完整且基线无糖尿病和感染性疾病的1045人进行分析.结果 研究人群5年间糖尿病的年龄标化累积发病率为8.8%,男性为9.8%,女性为8.2%.基线hs-CRP水平四分层后显示:男女两性糖尿病的累积发病率均有随hs-CRP水平升高而逐渐增加的趋势(P＜0.01).调整基线年龄、高血压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血糖、吸烟和腹部肥胖后,男女两性中hs-CRP≥3mg/L者发生糖尿病危险分别是hs-CRP＜1 mg/L者的3.30倍(95%CI:1.25～8.73)和2.58倍(95%CI:1.06～6.29).男女两性基线hs-CRP水平判定糖尿病是否发病的ROC曲线下面积分别为0.619(95%CI:0.536～0.701)和0.667(95%CI:0.585～0.749).结论 基线hs-CRP水平是糖尿病发病的独立预测因素,提示慢性炎症在糖尿病发生的病理过程中发挥重要作用.
目的 研究高敏C反應蛋白(hs-CRP)與5年糖尿病髮病風險的關繫.方法 研究對象來源于"中國多省市心血管病前瞻性隊列研究"中的北京大學社區隊列.2002年對該隊列45～74歲1541人進行心血管病危險因素調查和hs-CRP水平測定,2007年進行危險因素複查,對兩次資料完整且基線無糖尿病和感染性疾病的1045人進行分析.結果 研究人群5年間糖尿病的年齡標化纍積髮病率為8.8%,男性為9.8%,女性為8.2%.基線hs-CRP水平四分層後顯示:男女兩性糖尿病的纍積髮病率均有隨hs-CRP水平升高而逐漸增加的趨勢(P＜0.01).調整基線年齡、高血壓、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、甘油三酯、血糖、吸煙和腹部肥胖後,男女兩性中hs-CRP≥3mg/L者髮生糖尿病危險分彆是hs-CRP＜1 mg/L者的3.30倍(95%CI:1.25～8.73)和2.58倍(95%CI:1.06～6.29).男女兩性基線hs-CRP水平判定糖尿病是否髮病的ROC麯線下麵積分彆為0.619(95%CI:0.536～0.701)和0.667(95%CI:0.585～0.749).結論 基線hs-CRP水平是糖尿病髮病的獨立預測因素,提示慢性炎癥在糖尿病髮生的病理過程中髮揮重要作用.
목적 연구고민C반응단백(hs-CRP)여5년당뇨병발병풍험적관계.방법 연구대상래원우"중국다성시심혈관병전첨성대렬연구"중적북경대학사구대렬.2002년대해대렬45～74세1541인진행심혈관병위험인소조사화hs-CRP수평측정,2007년진행위험인소복사,대량차자료완정차기선무당뇨병화감염성질병적1045인진행분석.결과 연구인군5년간당뇨병적년령표화루적발병솔위8.8%,남성위9.8%,녀성위8.2%.기선hs-CRP수평사분층후현시:남녀량성당뇨병적루적발병솔균유수hs-CRP수평승고이축점증가적추세(P＜0.01).조정기선년령、고혈압、저밀도지단백담고순、고밀도지단백담고순、감유삼지、혈당、흡연화복부비반후,남녀량성중hs-CRP≥3mg/L자발생당뇨병위험분별시hs-CRP＜1 mg/L자적3.30배(95%CI:1.25～8.73)화2.58배(95%CI:1.06～6.29).남녀량성기선hs-CRP수평판정당뇨병시부발병적ROC곡선하면적분별위0.619(95%CI:0.536～0.701)화0.667(95%CI:0.585～0.749).결론 기선hs-CRP수평시당뇨병발병적독립예측인소,제시만성염증재당뇨병발생적병리과정중발휘중요작용.
Objective To analyze the association between hs-CRP(high-sensitivity C-reactive protein) levels in serum and the 5-year-accumulative-risk of diabetes in a general population.Methods Participants were from the cohort of Peking University residential community in the Chinese Multi- provincial Cohort Study(CMCS). Two surveys on cardiovascular risk factors and the measurements of serum hs-CRP levels were conducted in 2002 and 2007, respectively. Individuals with incomplete information and those having infectious diseases at baseline were excluded. A total of 1045 participants aged 45 to 74 years and free of diabetes at baseline were included in this analysis.Results The age-standardized 5-year accumulative incidence rate of diabetes was 8.8% (male:9.8%, female: 8.2% ) and increased significantly with the level of hs-CRP in both women and men (P＜0.01). After adjustment for age, hypertension, low-density liproprotein cholesterol, and high-density liproprotein cholesterol, triglycerides, fasting glucose, smoking status and central obesity,people with hs-CRP≥3 mg/L had a 3.30 times higher risk of developing diabetes in men and 2.58 times for women when compared to those with hs-CRP＜1 mg/L. The areas under the receiver operating characteristic curves of baseline hs-CRP level in predicting the incidence of diabetes were 0.619(95%CI:0.536-0.701 ) in men and 0.667(95%CI:0.585-0.749) in women. Conclusion Serum hs-CRP levels could predict the incidence of diabetes, indicating that inflammation might have great importance in the onset of diabetes.
