963例成熟T和自然杀伤细胞/T细胞淋巴瘤的临床病理特征分析
963례성숙T화자연살상세포/T세포림파류적림상병리특정분석
Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms
  • 万方数据
    中华病理学杂志 중화병이학잡지
    Chinese Journal of Pathology
    2010年 5期 291-295 ,共5页

    梁琼%叶子茵%苏祖兰%林汉良%邵春奎%林素暇%饶慧兰%梅开勇%赵彤%刘艳辉%罗东兰%朱梅刚%陈少红%林桐榆

    량경%협자인%소조란%림한량%소춘규%림소가%요혜란%매개용%조동%류염휘%라동란%주매강%진소홍%림동유

    淋巴瘤,T细胞%杀伤细胞,天然%病理学,临床 淋巴瘤,T細胞%殺傷細胞,天然%病理學,臨床
    림파류,T세포%살상세포,천연%병이학,림상
    Lymphoma T-cell%Killer cells,natural%Pathology,clinical
    目的 观察广东地区不同类型成熟T和自然杀伤(NK)细胞/T细胞淋巴瘤及其亚型的临床病理特点.方法 按WHO(2008版)标准重新评估广东地区2002-2006年1137例成熟T和NK/T细胞淋巴瘤患者.由多名血液病理医师复查,补做必要的免疫组织化学染色及原位杂交.结果 963例确诊为成熟T和NK/T细胞淋巴瘤,占同期所有淋巴瘤20.1%(963/4801),发生于结内319例(33.1%),结外644例(66.9%);非特殊型外周T细胞淋巴瘤293例(30.4%);结外鼻型NK/T细胞淋巴瘤281例(29.2%);间变性大细胞淋巴瘤(ALCL)198例(20.6%);血管免疫母细胞性T细胞淋巴瘤(AILT)46例(4.8%).男女比为1.99:1,发病中位年龄为44岁.非特殊型外周T细胞淋巴瘤好发于55～64岁;结外鼻型NK/T细胞淋巴瘤好发于25～54岁;间变性淋巴瘤激酶(ALK)阳性ALCL多见于年轻人而阴性多见于中老年人;AIIJT好发于65～74岁.结论 广东地区成熟T和 NK/T细胞淋巴瘤多见于结外,好发于男性,总体发病与年龄增长无明显关系,但具体类型有不同的年龄侧重群;常见的类型依次为非特殊型外周T细胞淋巴瘤、结外鼻型NK/T细胞淋巴瘤及ALCL;EB病毒感染与NK/T细胞淋巴瘤关系密切.
    목적 관찰엄동지구불동류형성숙T화자연살상(NK)세포/T세포림파류급기아형적림상병리특점.방법 안WHO(2008판)표준중신평고엄동지구2002-2006년1137례성숙T화NK/T세포림파류환자.유다명혈액병리의사복사,보주필요적면역조직화학염색급원위잡교.결과 963례학진위성숙T화NK/T세포림파류,점동기소유림파류20.1%(963/4801),발생우결내319례(33.1%),결외644례(66.9%);비특수형외주T세포림파류293례(30.4%);결외비형NK/T세포림파류281례(29.2%);간변성대세포림파류(ALCL)198례(20.6%);혈관면역모세포성T세포림파류(AILT)46례(4.8%).남녀비위1.99:1,발병중위년령위44세.비특수형외주T세포림파류호발우55～64세;결외비형NK/T세포림파류호발우25～54세;간변성림파류격매(ALK)양성ALCL다견우년경인이음성다견우중노년인;AIIJT호발우65～74세.결론 엄동지구성숙T화 NK/T세포림파류다견우결외,호발우남성,총체발병여년령증장무명현관계,단구체류형유불동적년령측중군;상견적류형의차위비특수형외주T세포림파류、결외비형NK/T세포림파류급ALCL;EB병독감염여NK/T세포림파류관계밀절.
    Objective To study the clinicopathologic features of various types of mature T-cell and natural killer ( NK)/T-cell lymphoma in Guangdong, China, with respect to the 2008 WHO classification of lymphoid neoplasms. Methods Eleven hundred and thirty-seven (1137) cases of mature T-cell or NK/T-cell lymphoma diagnosed during the period from 2002 to 2006 in Guangzhou area were retrieved. The clinical data, histologic features and immunohistochemical findings were reviewed by a panel of experienced hematopathologists. Additional immunostaining was performed if indicated. The cases were re-classified according to the 2008 WHO classification of lymphoid neoplasms. Results Nine hundred and sixty-three (963) cases fulfilled the diagnostic criteria of mature T-cell or NK/T-cell lymphoma and accounted for 20. 1% of all cases of lymphoma encountered during the same period (963/4801). A predominance of extranodal involvement was noted in 644 cases (66. 9% ) , while 319 cases (33. 1% ) showed mainly nodal disease. The prevalence of various lymphoma subtypes was as follows; peripheral T-cell lymphoma, unspecified (PTCL,NOS) 293 cases (30.4%), extranodal NK/T-cell lymphoma, nasal type 281 cases (29. 2% ) , anaplastic large cell lymphoma (ALCL) 198 cases (20. 6% ) , and angioimmunoblastic T-celllymphoma (AILT) 46 cases (4. 8% ). The male-to-female ratio was 1. 99. The median age of the patients was 44 years, with the peak age of PTCL,NOS, extranodal NK/T-cell lymphoma,nasal type and AILT being 55 to 64 years, 25 to 54 years and 65 to 74 years, respectively. ALK-positive ALCL occurred more frequently in young age, while the ALK-negative ALCL cases occurred mainly in the elderly. Conclusions Extranodal lesions predominate in mature T-cell and NK/T-cell various subtypes however varies. The most common subtype was PTCL.NOS, followed by extranodal NK/T-cell lymphoma, nasal type, ALCL and AILT. The relatively frequent occurrence of extranodal NK/T-cell lymphoma,nasal type in Guangdong area is likely associated with the high incidence of Epstein-Barr virus infection there.
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