CAJ | 학술논문

目的揭示奈西立肽对损伤的动脉血管壁血管重塑与血浆醛固酮的影响.方法随机将20只雄性新西兰大白兔分为两组,构建兔髂动脉的球囊损伤模型.术后对照组只喂标准兔饲料,实验组喂标准兔饲料+奈西立肽0.1 mg/(kg·d),皮下注射20 d.术后4周,活体取损伤的动脉组织.制作常规病理切片,采用天地公司TD2000病理图像分析系统测定血管重塑的各项指标.于术前、术后4周分别抽取静脉血测定血浆醛固酮水平.结果实验组血管内弹力膜下面积、外弹力膜下面积较对照组增大(P＜0.05).实验组残余管腔面积、面积狭窄率与对照组差异有统计学意义(P＜0.01).两组中膜面积差异无统计学意义(P＞0.05).实验组较对照组血浆醛固酮水平明显降低.结论奈西立肽可改善兔髂动脉球囊损伤后血管重塑,可能通过降低血浆醛固酮水平起作用.
목적 게시내서립태대손상적동맥혈관벽혈관중소여혈장철고동적영향.방법 수궤장20지웅성신서란대백토분위량조,구건토가동맥적구낭손상모형.술후대조조지위표준토사료,실험조위표준토사료+내서립태0.1 mg/(kg·d),피하주사20 d.술후4주,활체취손상적동맥조직.제작상규병리절편,채용천지공사TD2000병리도상분석계통측정혈관중소적각항지표.우술전、술후4주분별추취정맥혈측정혈장철고동수평.결과 실험조혈관내탄력막하면적、외탄력막하면적교대조조증대(P＜0.05).실험조잔여관강면적、면적협착솔여대조조차이유통계학의의(P＜0.01).량조중막면적차이무통계학의의(P＞0.05).실험조교대조조혈장철고동수평명현강저.결론 내서립태가개선토가동맥구낭손상후혈관중소,가능통과강저혈장철고동수평기작용.
Objective To reveal the relation between Nesiritide and vascular remodeling,the relation between Nesiritide and the levels of aldosterone.Methods 20 male New Zealand rabbits were randomly divided into two groups.All rabbit models were constructed with BC.After injury,the control group were fed with standard forage,the Nesiritide group received standard forage plus subcutaneous Nesiritide[0.1 mg/dissected free from arteria iliaca externa,processed for histological and morphological study by TD 2000 analysis system of pathology image.Data of vascular remodeling and the levels of plasma aldosterone were determined.Results There had significant difference between AUIEM and AUEEM(P ＜ 0.05),markedly significant difference was also found in residual cavity areas and ratios of stenosis(P ＜0.01).There had no significant difference between areas of media(P ＞ 0.05).Aldosterone reduced from the 28th day.Conclusions Nesiritide could benefit vascular remodeling after angioplasty,which might be through reducing aldosterone.