中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2009年
4期
245-247
,共3页
田振涛%徐勇%王锦%杨阔
田振濤%徐勇%王錦%楊闊
전진도%서용%왕금%양활
膀胱肿瘤%尿%细胞诊断学
膀胱腫瘤%尿%細胞診斷學
방광종류%뇨%세포진단학
Bladder neoplasms%Urine%Cytodiagnosis
目的 探讨尿脱落细胞吖啶橙荧光染色(AO-F)检查在膀胱癌诊断中的应用价值.方法 回顾性分析1016例膀胱癌患者资料,按临床分期、病理分级、肿瘤大小、数目、部位,手术治疗方式及有无血尿症状,分别计算AO-F阳性率,并进行统计学分析.结果 1016例患者尿样AO-F阳性率78.05%(793/1016),表浅癌和浸润癌患者阳性率分别为74.69%(611/818)和91.92%(182/198);病理分级≤Ⅱ级和Ⅲ级患者阳性率分别为67.24%(351/522)和90.37%(413/457);有无血尿症状患者阳性率分别为80.30%(750/934)和52.44%(43/82);肿瘤直径≥2 cm和<2 cm患者阳性率分别为79.87%(710/889)和65.35%(83/127);多发和单发肿瘤患者阳性率分别为83.07%(363/437)和74.27%(430/579);肿瘤累及膀胱三角区或膀胱颈部者阳性率为77.21%(105/136),累及其他部位者为78.07%(687/880);治疗方法TURBt、膀胱部分切除和膀胱全切除患者阳性率分别为69.68%(393/564),87.87%(268/305)和91.74%(100/109).AO-F阳性率与膀胱癌临床分期、病理分级、手术治疗方式、肿瘤大小、数目及有无血尿症状等因素有明显相关性,且与其临床分期、病理分级间存在正相关(r值分别为0.99和0.97);患者性别及肿瘤发生部位等因素与AO-F阳性率之间无相关性.结论 尿脱落细胞AO-F榆查诊断膀胱癌阳性率高,且简便、无创、经济、准确性高,可反复进行,可提高膀胱癌患者的早期诊断率,值得临床推广应用.
目的 探討尿脫落細胞吖啶橙熒光染色(AO-F)檢查在膀胱癌診斷中的應用價值.方法 迴顧性分析1016例膀胱癌患者資料,按臨床分期、病理分級、腫瘤大小、數目、部位,手術治療方式及有無血尿癥狀,分彆計算AO-F暘性率,併進行統計學分析.結果 1016例患者尿樣AO-F暘性率78.05%(793/1016),錶淺癌和浸潤癌患者暘性率分彆為74.69%(611/818)和91.92%(182/198);病理分級≤Ⅱ級和Ⅲ級患者暘性率分彆為67.24%(351/522)和90.37%(413/457);有無血尿癥狀患者暘性率分彆為80.30%(750/934)和52.44%(43/82);腫瘤直徑≥2 cm和<2 cm患者暘性率分彆為79.87%(710/889)和65.35%(83/127);多髮和單髮腫瘤患者暘性率分彆為83.07%(363/437)和74.27%(430/579);腫瘤纍及膀胱三角區或膀胱頸部者暘性率為77.21%(105/136),纍及其他部位者為78.07%(687/880);治療方法TURBt、膀胱部分切除和膀胱全切除患者暘性率分彆為69.68%(393/564),87.87%(268/305)和91.74%(100/109).AO-F暘性率與膀胱癌臨床分期、病理分級、手術治療方式、腫瘤大小、數目及有無血尿癥狀等因素有明顯相關性,且與其臨床分期、病理分級間存在正相關(r值分彆為0.99和0.97);患者性彆及腫瘤髮生部位等因素與AO-F暘性率之間無相關性.結論 尿脫落細胞AO-F榆查診斷膀胱癌暘性率高,且簡便、無創、經濟、準確性高,可反複進行,可提高膀胱癌患者的早期診斷率,值得臨床推廣應用.
목적 탐토뇨탈락세포아정등형광염색(AO-F)검사재방광암진단중적응용개치.방법 회고성분석1016례방광암환자자료,안림상분기、병리분급、종류대소、수목、부위,수술치료방식급유무혈뇨증상,분별계산AO-F양성솔,병진행통계학분석.결과 1016례환자뇨양AO-F양성솔78.05%(793/1016),표천암화침윤암환자양성솔분별위74.69%(611/818)화91.92%(182/198);병리분급≤Ⅱ급화Ⅲ급환자양성솔분별위67.24%(351/522)화90.37%(413/457);유무혈뇨증상환자양성솔분별위80.30%(750/934)화52.44%(43/82);종류직경≥2 cm화<2 cm환자양성솔분별위79.87%(710/889)화65.35%(83/127);다발화단발종류환자양성솔분별위83.07%(363/437)화74.27%(430/579);종류루급방광삼각구혹방광경부자양성솔위77.21%(105/136),루급기타부위자위78.07%(687/880);치료방법TURBt、방광부분절제화방광전절제환자양성솔분별위69.68%(393/564),87.87%(268/305)화91.74%(100/109).AO-F양성솔여방광암림상분기、병리분급、수술치료방식、종류대소、수목급유무혈뇨증상등인소유명현상관성,차여기림상분기、병리분급간존재정상관(r치분별위0.99화0.97);환자성별급종류발생부위등인소여AO-F양성솔지간무상관성.결론 뇨탈락세포AO-F유사진단방광암양성솔고,차간편、무창、경제、준학성고,가반복진행,가제고방광암환자적조기진단솔,치득림상추엄응용.
Objective To investigate the diagnostic value of acridine orange fluorescene(AO-F) in bladder cancers. Methods One thousand and sixteen bladder cancer patients were reviewed retro-spectively. The positive-rates of AO-F in different stages, grades, size, quantity, position of tumors, hematuria and treatment ways were evaluated. Results The total positive rate of AO-F was 78.05 % (793/1016). The positive-rate was 74.69% (611/818) in superficial stage and 91.92% (182/198) in invasive bladder cancer, 67.24% (351/522) in grade Ⅰ and Ⅱ , 90. 37% (413/457) in grade Ⅲ. The percentage of positive AO-F was 80.30% (750/934) in patients with hematuria, 52.44% (43/82) in patients without hematuria. The percentage was 79.87% (710/889) when the tumor size was more than 2 cm, 65.35% (83/127) when size less than 2 cm. 83.07% (363/437) sample was positive in multiple tumors, 74.27% (430/579) in single tumor. The percentage was 77.21% (105/136) in tumors involving trigone or neck of bladder, 78.07% (687/880) in tumors without involving these re-gions. There was 69.68% (393/564) in treatment with TURBt, 87.87% (268/305) in partial resec-tion, 91.74% (100/109) in total resection. A good association was observed between stage, grade, hematuria appearance, tumor size, quantity of carcinoma, treatment way and AO-F positive-rate, and a linear correlation was present between grade, stage and positive cytology. There was no significant association between position of the tumor and AO-F positive-rate. Conclusions The function of AO-F is significant in diagnosis of bladder cancer.
