CAJ | 학술논문

目的研究宫颈炎症患者阴道局部免疫状态与疾病发生的关系.方法应用酶联免疫吸附试验(ELISA)检测60例解脲支原体(UU)宫颈炎(UU组)、60例人型支原体(MH)宫颈炎(MH组)、60例沙眼衣原体(CT)宫颈炎(CT组)、30例淋病奈瑟菌(NG)宫颈炎(NG组)、60例宫颈糜烂患者(EC组)及与上述疾病相同例数的对照组(正常妇女)阴道灌洗液中自细胞介素(IL)-8和肿瘤坏死因子(TNF)-α的水平.结果 (1)阴道灌洗液中IL-8水平:MH组为(371±34)ng/L、CT组为(369±31)ng/L、NG组为(339±36)ng/L,3组的同期对照组分别为(341±32)ng/L、(338±33)ng/L、(316±34)ng/L,两两比较差异均有统计学意义(均P<0.01);UU组、EC组与同期对照组比较,差异均无统计学意义(均P>0.05).(2)阴道灌洗液中TNF-±水平:除EC组外,其余各组均显著高于同期对照组,两两比较差异均有统计学意义(均P<0.01).结论在各种宫颈炎症的发病机制中,阴道局部免疫机制都发挥了重要作用;IL-8在MH、CT、NG引起的子宫颈特殊炎症的发病中可能具有更重要的作用.
목적 연구궁경염증환자음도국부면역상태여질병발생적관계.방법 응용매련면역흡부시험(ELISA)검측60예해뇨지원체(UU)궁경염(UU조)、60례인형지원체(MH)궁경염(MH조)、60례사안의원체(CT)궁경염(CT조)、30례임병내슬균(NG)궁경염(NG조)、60례궁경미란환자(EC조)급여상술질병상동례수적대조조(정상부녀)음도관세액중자세포개소(IL)-8화종류배사인자(TNF)-α적수평.결과 (1)음도관세액중IL-8수평:MH조위(371±34)ng/L、CT조위(369±31)ng/L、NG조위(339±36)ng/L,3조적동기대조조분별위(341±32)ng/L、(338±33)ng/L、(316±34)ng/L,량량비교차이균유통계학의의(균P<0.01);UU조、EC조여동기대조조비교,차이균무통계학의의(균P>0.05).(2)음도관세액중TNF-±수평:제EC조외,기여각조균현저고우동기대조조,량량비교차이균유통계학의의(균P<0.01).결론 재각충궁경염증적발병궤제중,음도국부면역궤제도발휘료중요작용;IL-8재MH、CT、NG인기적자궁경특수염증적발병중가능구유경중요적작용.
Objective To investigate the relationship between local immune status of vagina and the occurrence of disease in patients with cervicitis. Methods ELISA were used to detect the level of interleukin(IL)-8 and tumor necrosis factor(TNF)-α in vaginal douche of patients with eervicitis due to ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis, neisseria gonorrhoeae and cervical erosion. Results Compared with the control group, the level of IL-8 in vaginal douche of patients with mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis was significantly higher and there was significant difference ng/L: 371±34, 369±31, 339±36, vs 341±32, 338±33, 316±24, (all P<0.01). Comparing the level of IL-8 in vaginal douche of patients with ureaplasma urealyticum eervicitis and cervical erosion with that of control group, there was no statistical difference(all P>0.05). The level of TNF-α in vaginal douche of each group was remarkably higher than that of control group except for patients with cervical erosion. And statistically significant difference was found between them (all P<0.01). Conclusion With regards to the pathogenesis of cervicitis, local immune mechanism of vagina plays an important role in the occurrence of cervicitis. The role of IL-8 in pathogenesis of myeoplasma hominis cervieitis, chlamydia trachomatis cervieitis and neisseria gonorrhoeae cervicitis is likely to be more important.