CAJ | 학술논문

目的研究低频重复经颅磁刺激(rTMS)对精神分裂症难治性慢性幻听症状的疗效.方法将46例精神分裂症伴慢性幻听患者随机分为研究组(23例)和对照组(23例).研究组在原有抗精神病药物种类及剂量不变的同时给予经左侧颞顶叶的2周共10次低频(1Hz)rTMS刺激,对照组采用假rTMS刺激.治疗前后对两组分别进行AHRS听幻觉量表及临床疗效总评量表(CGI)评定幻听症状的变化,并对治疗有效者于3个月后随访.结果研究组治疗前、后AHRS评分分别为(8.1±2.5)和(3.5±1.5);对照组为(7.8±2.6)和(6.5±2.1),研究组疗效明显优于对照组(F=20.3,P<0.05).所有患者均完成试验,未见有严重的副反应出现.结论低频rTMS治疗精神分裂症难治性慢性幻听症状,疗效肯定且安全性好.
목적 연구저빈중복경로자자격(rTMS)대정신분렬증난치성만성환은증상적료효.방법 장46례정신분렬증반만성환은환자수궤분위연구조(23례)화대조조(23례).연구조재원유항정신병약물충류급제량불변적동시급여경좌측섭정협적2주공10차저빈(1Hz)rTMS자격,대조조채용가rTMS자격.치료전후대량조분별진행AHRS은환각량표급림상료효총평량표(CGI)평정환은증상적변화,병대치료유효자우3개월후수방.결과 연구조치료전、후AHRS평분분별위(8.1±2.5)화(3.5±1.5);대조조위(7.8±2.6)화(6.5±2.1),연구조료효명현우우대조조(F=20.3,P<0.05).소유환자균완성시험,미견유엄중적부반응출현.결론 저빈rTMS치료정신분렬증난치성만성환은증상,료효긍정차안전성호.
Objective To explore the effects of slow repetitive transcranial magnetic stimulation (rTMS) for treating chronic auditory hallucinations in schizophrenia. Methods Forty-six schizophrenic patients with chron-ic auditory hallucinations were randomly divided to active slow rTMS group (23 cases) and sham rTMS group (23 cases). All patients received antipsychotic drugs without change throughout the study period. The effects were assessed by Auditory Hallucination Rating Scale (AHRS) and Clinical Global Impression (CGI). Results The scores of AHRS in rTMS group before and after treatment were(8, 1±2.5) and (3.5±1.5), those of con-trol group were (7.8±2.6) and (6.5±2.1). The efficacy of the rTMS group was significantly superior to that of the control group (F=20.3,P<0.05). All patients completed the trial, and no serious side effects were found. Conclusion Slow rTMS is effective for treating chronic auditory hallucinations in schizophrenia.