CAJ | 학술논문

背景与目的:癌肉瘤(carcinosarcoma,CS)是指一种在同一肿瘤中存有癌和肉瘤两种成分的混合性恶性肿瘤,肺癌肉瘤更是一种罕见的肺部恶性肿瘤,5年生存率低.本研究的目的是探讨肺癌肉瘤的临床特征对生存情况的影响.方法:通过收集64例肺癌肉瘤患者的临床资料,回顾性分析了患者的性别、年龄、p-TNM分期、肿瘤位置、化疗和手术方式等凶素对预后的影响.结果:64例肺痛肉瘤患者术后5年生存率为14.1%.早期(Ⅰ、Ⅱ)和晚期(Ⅲ、Ⅳ)组5年生存率分别为28.6%和2.8%,差异有统计学意义(P=0.003);全肺切除、肺叶切除及姑息性手术组的5年生存率分别为33.3%、9.5%和0,差异有统计学意义(P=0.039).结论:p-TNM分期、手术方式与肺癌肉瘤的生存情况关系密切.早期发现,早期行根治性手术,对延长患者的生存非常有意义.
배경여목적:암육류(carcinosarcoma,CS)시지일충재동일종류중존유암화육류량충성분적혼합성악성종류,폐암육류경시일충한견적폐부악성종류,5년생존솔저.본연구적목적시탐토폐암육류적림상특정대생존정황적영향.방법:통과수집64례폐암육류환자적림상자료,회고성분석료환자적성별、년령、p-TNM분기、종류위치、화료화수술방식등흉소대예후적영향.결과:64례폐통육류환자술후5년생존솔위14.1%.조기(Ⅰ、Ⅱ)화만기(Ⅲ、Ⅳ)조5년생존솔분별위28.6%화2.8%,차이유통계학의의(P=0.003);전폐절제、폐협절제급고식성수술조적5년생존솔분별위33.3%、9.5%화0,차이유통계학의의(P=0.039).결론:p-TNM분기、수술방식여폐암육류적생존정황관계밀절.조기발현,조기행근치성수술,대연장환자적생존비상유의의.
Background and purpose: Carcinosarcoma of the lung is a rare malignant pulmonary neoplasm,which including epithelial and parenchymal malignant structure with a poor prognosis. The purpose of this study was to describe the clinicopathologic characteristics and the survival of pulmonary carcinosarcoma. Methods: From Jan.1980 to Dec. 2006, 64 patients with pulmonary carcinosarcoma who underwent surgical treatment were retrospectively analyzed. Results: The overall 5-year survival rate of the patients was 14.1%. There was significant difference between stage Ⅰ/Ⅱ and stage Ⅲ/Ⅳ disease (28.6% vs 2.8%, P=0.003), respectively. The 5-year survival rates of lobectomy, pneumonectomy and palliative resection were 3 3.3 %, 2.8% and 0% ( P=0.003 ), respectively. Conclusion:p-TNM and operative pattern were correlated with survival. Early diagnosis and radical operation are important to the survival of the patients with pulmonary carcinosarcoma.