CAJ | 학술논문

99mTc-depreotide是一种新型生长抑素受体显像剂,能与多种肿瘤细胞高表达的生长抑素受体相结合,对肿瘤的良、恶性评估具有很高的特异性和敏感性,可定性、定位诊断多种生长抑素受体阳性肿瘤,特别是对非小细胞肺癌的定位诊断及鉴别诊断更具有临床价值.Depreotide的生物学特点、放射性核素标记、药物体内分布及肿瘤显像等方面的研究都有了新的进展.
99mTc-depreotide시일충신형생장억소수체현상제,능여다충종류세포고표체적생장억소수체상결합,대종류적량、악성평고구유흔고적특이성화민감성,가정성、정위진단다충생장억소수체양성종류,특별시대비소세포폐암적정위진단급감별진단경구유림상개치.Depreotide적생물학특점、방사성핵소표기、약물체내분포급종류현상등방면적연구도유료신적진전.
As a new somatostatin receptor imaging agent,99mTc-depreotide can bind with somatostatin receptors(SSTR)which over express in many sorts of tumor cells.It shows high sensitivity and speciality on evaluating the malignancy and localization of tumors with SSTR overexpression,especially for non-small cell lung cancer(NSCLC).This article gives a review on the bioligy characteristics,radioisotope labeling,biodistribution and tumor imaging of depreotide.