中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2011年
1期
84-87
,共4页
边建朝%秦启亮%云中杰%刘源%刘传蛟%宋术亮%骆效宏%翟丽屏%高杰%梁超轲%Sujuan GAO
邊建朝%秦啟亮%雲中傑%劉源%劉傳蛟%宋術亮%駱效宏%翟麗屏%高傑%樑超軻%Sujuan GAO
변건조%진계량%운중걸%류원%류전교%송술량%락효굉%적려병%고걸%량초가%Sujuan GAO
老年人%硒%认知能力
老年人%硒%認知能力
노년인%서%인지능력
Aged%Selenium%Cognitive ability
目的 探讨老年人群认知能力与环境硒水平的相关性,验证体内不同硒水平对老年人群认知能力的影响.方法 选择山东省外环境硒水平不同的淄川区和高密市为调查点,其中淄川区为适硒[硒摄入量(46.73±24.36)mg·kg-1·d-1]地区,高密市为低硒[硒摄入量(11.66±4.72)mg·kg-1·d-1]地区.采用分层抽样方法,分别抽取终身居住于当地年龄≥65岁的农村老年人各500人,利用膳食摄入量调查表,对老年人进行近1年的回顾性膳食调查,计算每日硒总摄入量.采用美国印第安纳大学提供的社区痴呆筛查量表(CSID)、故事记忆测试、动物流畅性测验评定老年人群的认知能力;采用美国老年痴呆症登记联盟(CERAD)词表中提供的方法,对老年人群进行学习测试、学习记忆测试;采用现场采访评定方式,通过问卷调查形式获得老年人群认知能力资料,分析体内硒水平与老年人群认知能力之间的相关性.采集老年人群指甲和静脉血,应用荧光分光光度法检测指甲硒和血硒水平.结果 适硒与低硒地区老年人群硒摄入量[(46.73±24.36)、(11.66±4.72)mg.kg-1·d-1]、指甲硒[(0.605±0.163)、(0.405±0.086)mg/kg]和血硒[(147.44±17.42)、(117.38±22.48)μg/L]组间比较差异有统计学意义(U值分别为31.59、25.00、23.67,P均＜0.01);硒摄入量与指甲硒和血硒、指甲硒与血硒之间存在正相关(r值分别为0.51、0.46、0.60,P均＜0.01).老年人群体内硒水平与认知能力,除动物名词叙述测试外,CSID总计分、故事记忆、回忆测试、学习记忆测试组间比较差异有统计学意义(F值分别为2.56、9.18、7.48、4.42,P＜0.05);剔除可能混杂因素的影响后,除学习记忆测试外,老年人群体内硒水平与CSID总计分、故事记忆、动物流畅、学习测试有明显的正相关(r值分别为0.076、0.138、0.042、0.107,P＜0.05或＜0.01).结论 环境硒水平与老年人群的认知能力之间呈正相关;环境硒水平高的地区老年人群的认知能力明显高于环境硒水平低的地区.
目的 探討老年人群認知能力與環境硒水平的相關性,驗證體內不同硒水平對老年人群認知能力的影響.方法 選擇山東省外環境硒水平不同的淄川區和高密市為調查點,其中淄川區為適硒[硒攝入量(46.73±24.36)mg·kg-1·d-1]地區,高密市為低硒[硒攝入量(11.66±4.72)mg·kg-1·d-1]地區.採用分層抽樣方法,分彆抽取終身居住于噹地年齡≥65歲的農村老年人各500人,利用膳食攝入量調查錶,對老年人進行近1年的迴顧性膳食調查,計算每日硒總攝入量.採用美國印第安納大學提供的社區癡呆篩查量錶(CSID)、故事記憶測試、動物流暢性測驗評定老年人群的認知能力;採用美國老年癡呆癥登記聯盟(CERAD)詞錶中提供的方法,對老年人群進行學習測試、學習記憶測試;採用現場採訪評定方式,通過問捲調查形式穫得老年人群認知能力資料,分析體內硒水平與老年人群認知能力之間的相關性.採集老年人群指甲和靜脈血,應用熒光分光光度法檢測指甲硒和血硒水平.結果 適硒與低硒地區老年人群硒攝入量[(46.73±24.36)、(11.66±4.72)mg.kg-1·d-1]、指甲硒[(0.605±0.163)、(0.405±0.086)mg/kg]和血硒[(147.44±17.42)、(117.38±22.48)μg/L]組間比較差異有統計學意義(U值分彆為31.59、25.00、23.67,P均＜0.01);硒攝入量與指甲硒和血硒、指甲硒與血硒之間存在正相關(r值分彆為0.51、0.46、0.60,P均＜0.01).老年人群體內硒水平與認知能力,除動物名詞敘述測試外,CSID總計分、故事記憶、迴憶測試、學習記憶測試組間比較差異有統計學意義(F值分彆為2.56、9.18、7.48、4.42,P＜0.05);剔除可能混雜因素的影響後,除學習記憶測試外,老年人群體內硒水平與CSID總計分、故事記憶、動物流暢、學習測試有明顯的正相關(r值分彆為0.076、0.138、0.042、0.107,P＜0.05或＜0.01).結論 環境硒水平與老年人群的認知能力之間呈正相關;環境硒水平高的地區老年人群的認知能力明顯高于環境硒水平低的地區.
목적 탐토노년인군인지능력여배경서수평적상관성,험증체내불동서수평대노년인군인지능력적영향.방법 선택산동성외배경서수평불동적치천구화고밀시위조사점,기중치천구위괄서[서섭입량(46.73±24.36)mg·kg-1·d-1]지구,고밀시위저서[서섭입량(11.66±4.72)mg·kg-1·d-1]지구.채용분층추양방법,분별추취종신거주우당지년령≥65세적농촌노년인각500인,이용선식섭입량조사표,대노년인진행근1년적회고성선식조사,계산매일서총섭입량.채용미국인제안납대학제공적사구치태사사량표(CSID)、고사기억측시、동물류창성측험평정노년인군적인지능력;채용미국노년치태증등기련맹(CERAD)사표중제공적방법,대노년인군진행학습측시、학습기억측시;채용현장채방평정방식,통과문권조사형식획득노년인군인지능력자료,분석체내서수평여노년인군인지능력지간적상관성.채집노년인군지갑화정맥혈,응용형광분광광도법검측지갑서화혈서수평.결과 괄서여저서지구노년인군서섭입량[(46.73±24.36)、(11.66±4.72)mg.kg-1·d-1]、지갑서[(0.605±0.163)、(0.405±0.086)mg/kg]화혈서[(147.44±17.42)、(117.38±22.48)μg/L]조간비교차이유통계학의의(U치분별위31.59、25.00、23.67,P균＜0.01);서섭입량여지갑서화혈서、지갑서여혈서지간존재정상관(r치분별위0.51、0.46、0.60,P균＜0.01).노년인군체내서수평여인지능력,제동물명사서술측시외,CSID총계분、고사기억、회억측시、학습기억측시조간비교차이유통계학의의(F치분별위2.56、9.18、7.48、4.42,P＜0.05);척제가능혼잡인소적영향후,제학습기억측시외,노년인군체내서수평여CSID총계분、고사기억、동물류창、학습측시유명현적정상관(r치분별위0.076、0.138、0.042、0.107,P＜0.05혹＜0.01).결론 배경서수평여노년인군적인지능력지간정정상관;배경서수평고적지구노년인군적인지능력명현고우배경서수평저적지구.
Objective To explore the correlation between environmental selenium(Se) levels and cognitive ability among rural elderly population, and the effect of Se on cognitive skill of the elderly. Methods Two study sites(Zichuan district and Gaomi city of Shandong) with different environmental Se levels were selected according to rural elderly people ≥ 65 years were extracted by stratified random sampling method in each site. A retrospective survey was carried out using dietary intake questionnaire for the elderly for the past 1 year, and their daily total Se intake was calculated. Questionnaire was also used to obtain cognitive skill information in the elderly people. The Community Screening Instrument for Dementia, the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Learning Test, the Indiana University (IU) Story Recall Test, the Animal Fluency Test, and the IU Token Test were applied to assess the cognitive ability. Se level in these samples was analyzed. Correlation between the Se levels of environment and those of human body were analyzed statistically. Results There were 0.163), (0.405 ± 0.086)]mg/kg and nail Se[(147.44 ± 17.42), (117.38 ± 22.48)μg/L]between the two groups (U = 31.59, 25.00, 23.67, all P ＜ 0.01 ). There were positive correlation among the nail Se, environmental Se and Se in all subjects(r = 0.51,0.46, 0.60, all P ＜ 0.01 ). The differences of the CSID total score, the CERAD Word List Learning Test, the CERAD Word List Recall Test and the IU Story Recall Test between the two sites were statistically significant(F = 2.56, 9.18, 7.48, 4.42, all P ＜ 0.05), excluding the Indiana University Story Recall Test.After eliminating possible confounding factors, the Se levels and the CSID total score, the IU Story Recall Test, the Animal Fluency Test and the IU Story Token Test had a significantly positive correlation (r = 0.076, 0.138, 0.042,0.107, P ＜ 0.05 or ＜ 0.01 ), excluding the CERAD Word List Learning Test. Conclusions This study supports the hypothesis that a life long low Se level is associated with lower cognitive ability. The cognitive abilities in the elderly population lived in areas with high environmental selenium levels are significantly higher than that of the elderly lived in areas with low environmental selenium levels.
