中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
2期
143-145
,共3页
高艳虹%徐锦霞%张江蓉%昌菁%卢维晟%王一尘%潘志红
高豔虹%徐錦霞%張江蓉%昌菁%盧維晟%王一塵%潘誌紅
고염홍%서금하%장강용%창정%로유성%왕일진%반지홍
2型糖尿病%骨密度%老年男性%甲状旁腺素%25羟维生素D3
2型糖尿病%骨密度%老年男性%甲狀徬腺素%25羥維生素D3
2형당뇨병%골밀도%노년남성%갑상방선소%25간유생소D3
Type 2-Diabetes%Bone mineral density%Elderly man%Parathyroid hormone%25-(OH)-Vitamin D3
目的 探讨老年男性2型糖尿病患者主要钙调激素甲状旁腺素(PTH)和维生素D的变化对骨密度的影响.方法 应用双能X线骨密度仪测定60例老年男性2型糖尿病患者的腰椎和髋部骨密度,检测血清中骨代谢及血糖相关的指标,并根据骨密度测定结果将60例老年男性2型糖尿病患者分为骨量减少组(32例)、骨质疏松组(12例)、正常组(16例),测定3组的血清PTH和25羟维生素D3,分析其与患者不同部位骨密度的相关性.结果 依据患者腰椎或髋部的骨密度值,骨质疏松的检出率为20.0％(12/60),骨量减少的检出率为53.3％(32/60).3组的血清PTH比较差异有统计学意义(F=3.32,P=0.043),骨量减少组、骨质疏松组与正常组相比,PTH水平明显上升[(44.87±10.62)、(50.24±20.32)μg/L与(36.96±12.36)μg/L,P均＜0.05].但25羟维生素D3浓度3组比较差异无统计学意义(P＞0.05).相关分析显示,PTH水平与髋部骨矿面密度(BMD)呈显著负相关(r=-0.224,P ＜0.05),与腰椎BMD无显著相关性(r=-0.187,P＞0.05).结论 老年男性2型糖尿病患者的髋部BMD与血清PTH浓度负相关.
目的 探討老年男性2型糖尿病患者主要鈣調激素甲狀徬腺素(PTH)和維生素D的變化對骨密度的影響.方法 應用雙能X線骨密度儀測定60例老年男性2型糖尿病患者的腰椎和髖部骨密度,檢測血清中骨代謝及血糖相關的指標,併根據骨密度測定結果將60例老年男性2型糖尿病患者分為骨量減少組(32例)、骨質疏鬆組(12例)、正常組(16例),測定3組的血清PTH和25羥維生素D3,分析其與患者不同部位骨密度的相關性.結果 依據患者腰椎或髖部的骨密度值,骨質疏鬆的檢齣率為20.0％(12/60),骨量減少的檢齣率為53.3％(32/60).3組的血清PTH比較差異有統計學意義(F=3.32,P=0.043),骨量減少組、骨質疏鬆組與正常組相比,PTH水平明顯上升[(44.87±10.62)、(50.24±20.32)μg/L與(36.96±12.36)μg/L,P均＜0.05].但25羥維生素D3濃度3組比較差異無統計學意義(P＞0.05).相關分析顯示,PTH水平與髖部骨礦麵密度(BMD)呈顯著負相關(r=-0.224,P ＜0.05),與腰椎BMD無顯著相關性(r=-0.187,P＞0.05).結論 老年男性2型糖尿病患者的髖部BMD與血清PTH濃度負相關.
목적 탐토노년남성2형당뇨병환자주요개조격소갑상방선소(PTH)화유생소D적변화대골밀도적영향.방법 응용쌍능X선골밀도의측정60례노년남성2형당뇨병환자적요추화관부골밀도,검측혈청중골대사급혈당상관적지표,병근거골밀도측정결과장60례노년남성2형당뇨병환자분위골량감소조(32례)、골질소송조(12례)、정상조(16례),측정3조적혈청PTH화25간유생소D3,분석기여환자불동부위골밀도적상관성.결과 의거환자요추혹관부적골밀도치,골질소송적검출솔위20.0％(12/60),골량감소적검출솔위53.3％(32/60).3조적혈청PTH비교차이유통계학의의(F=3.32,P=0.043),골량감소조、골질소송조여정상조상비,PTH수평명현상승[(44.87±10.62)、(50.24±20.32)μg/L여(36.96±12.36)μg/L,P균＜0.05].단25간유생소D3농도3조비교차이무통계학의의(P＞0.05).상관분석현시,PTH수평여관부골광면밀도(BMD)정현저부상관(r=-0.224,P ＜0.05),여요추BMD무현저상관성(r=-0.187,P＞0.05).결론 노년남성2형당뇨병환자적관부BMD여혈청PTH농도부상관.
Objective To explore the impact of calciotropic hormones,such as parathyroid hormone (PTH)and vitamin D,on bone mineral density(BMD)in the old men with type 2-Diabetes.Methods Sixty elderly men with type 2-Diabetes were submitted to dual-energy X-ray absorptiometry to evaluate the BMD at lumbar spine and hip.Fasting blood samples were collected to evaluate the indexes of bone metablism and blood glucose.PTH and 25-(OH)-Vitamin D3 were measured and analyzed for their correlation with BMD at different sites.Results In all patients,the percentage of osteoporosis and osteopenia accounted for 20.0％ and 53.3％ of the patients according to BMD at lumbar or hip.Compared with the patient group with normal BMD,serum PTH was significantly higher in the patient group with osteopenia or osteoporsis([44.87 ± 10.62]μg/L vs[36.96 ±12.36]μg/L,P ＜ 0.05 ;[50.24 ± 20.32]μg/L vs[36.96 ± 12.36]μg/L,P ＜ 0.05).But there was no difference in 25-(OH)-Vitamin D3 levels between all groups.PTH was correlated negatively with BMD at hip (r =-0.224,P ＜ 0.05),but not significantly correlated with BMD at lumbar(r =-0.187,P ＞ 0.05)Conclusions Serum PTH was correlated negatively with BMD at hip in elderly man with type 2-Diabetes.
