CAJ | 학술논문

探讨不同糖耐量个体氧化应激与β细胞第一时相分泌功能的关系.比较各组8-羟基脱氧尿苷(8-OHdG)、丙二醛、超氧化物歧化酶(SOD)、脂联素、0～10 min胰岛素曲线下面积(AUC)、急性胰岛素反应(AIR3-5)等指标.发现随病情发展,氧化应激指标水平升高,抗氧化酶活性、脂联素及β细胞第一时相分泌功能下降,丙二醛、8-OHdG与脂联素、稳态模型评估的胰岛β细胞功能指数(HOMA-β)、AUC、AIR3-5负相关,SOD与脂联素、HOMA-β、AUC、AIR3-5正相关,8-OHdG、SOD是AIR3-5的独立相关因素.氧化应激对β细胞第一时相分泌功能有显著影响,可能与2型糖尿病的发病机制密切相关.
탐토불동당내량개체양화응격여β세포제일시상분비공능적관계.비교각조8-간기탈양뇨감(8-OHdG)、병이철、초양화물기화매(SOD)、지련소、0～10 min이도소곡선하면적(AUC)、급성이도소반응(AIR3-5)등지표.발현수병정발전,양화응격지표수평승고,항양화매활성、지련소급β세포제일시상분비공능하강,병이철、8-OHdG여지련소、은태모형평고적이도β세포공능지수(HOMA-β)、AUC、AIR3-5부상관,SOD여지련소、HOMA-β、AUC、AIR3-5정상관,8-OHdG、SOD시AIR3-5적독립상관인소.양화응격대β세포제일시상분비공능유현저영향,가능여2형당뇨병적발병궤제밀절상관.
The relationship between oxidative stress and the first-phase of pancreatic β cell insulin secretion in subjects with different statuses of glucose tolerance was explored. Fasting adiponectin, 8-hydroxydeoxyguanosin ( 8-OHdG), malondialdehyde ( MDA ), superoxide dismutase ( SOD ), insulin area under the curve ( AUC ) from 0 to 10 min, and AIR3-5 were measured. The levels of oxidative stress-related markers were elevated, the activities of superoxide dismutase,adiponectin, and first-phase of insulin secretion were reduced with the disease progression. MDA and 8-OHdG were negatively correlated with adiponectin, homeostasis model assessment β cell function index ( HOMA-β ),AUC ,and AIR3-5. SOD was positively correlated with adiponectin, HOMA-β, AUC, AIR3-5. The plasma 8-OHdG and SOD were independently associated with AIR3-5. Oxidative stress exerts a significant effect on the first phase of pancreatic β cell insulin secretion, which may contribute to the pathogenesis of type 2 diabetes.