国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
4期
316-319
,共4页
食管肿瘤%癌,鳞状细胞%DNA结合蛋白质类%肿瘤抑制蛋白质p53
食管腫瘤%癌,鱗狀細胞%DNA結閤蛋白質類%腫瘤抑製蛋白質p53
식관종류%암,린상세포%DNA결합단백질류%종류억제단백질p53
Esophageal neoplasms%Carcinoma,squamous cell%DNA-binding proteins%Tumor suppressor protein p53
目的 探讨食管鳞癌组织中P53与P73蛋白的表达及其相关性.方法 采用免疫组织化学S-P方法检测46例食管鳞癌组织及30例正常黏膜组织中P53和P73蛋白的表达,并分析两者与相关临床特征的关系及两者之间的相关性.结果 在食管鳞癌组织中P53和P73蛋白的表达与其在正常黏膜中的表达差异具有统计学意义(P=0.007,0.008).P53表达与性别和淋巴转移相关(P=0.047,0.028),而与年龄、分化程度、浸润深度和大体分型无关(P>0.05).P73表达与分化程度和淋巴转移相关(P=0.023,0.035);与年龄、性别、浸润深度和大体分型无关(P>0.05).P53和P73在食管鳞癌的表达正相关(r=0.359,P=0.014).结论 P53和P73与食管鳞癌的发生密切相关,而且共同参与食管鳞癌的发展过程.
目的 探討食管鱗癌組織中P53與P73蛋白的錶達及其相關性.方法 採用免疫組織化學S-P方法檢測46例食管鱗癌組織及30例正常黏膜組織中P53和P73蛋白的錶達,併分析兩者與相關臨床特徵的關繫及兩者之間的相關性.結果 在食管鱗癌組織中P53和P73蛋白的錶達與其在正常黏膜中的錶達差異具有統計學意義(P=0.007,0.008).P53錶達與性彆和淋巴轉移相關(P=0.047,0.028),而與年齡、分化程度、浸潤深度和大體分型無關(P>0.05).P73錶達與分化程度和淋巴轉移相關(P=0.023,0.035);與年齡、性彆、浸潤深度和大體分型無關(P>0.05).P53和P73在食管鱗癌的錶達正相關(r=0.359,P=0.014).結論 P53和P73與食管鱗癌的髮生密切相關,而且共同參與食管鱗癌的髮展過程.
목적 탐토식관린암조직중P53여P73단백적표체급기상관성.방법 채용면역조직화학S-P방법검측46례식관린암조직급30례정상점막조직중P53화P73단백적표체,병분석량자여상관림상특정적관계급량자지간적상관성.결과 재식관린암조직중P53화P73단백적표체여기재정상점막중적표체차이구유통계학의의(P=0.007,0.008).P53표체여성별화림파전이상관(P=0.047,0.028),이여년령、분화정도、침윤심도화대체분형무관(P>0.05).P73표체여분화정도화림파전이상관(P=0.023,0.035);여년령、성별、침윤심도화대체분형무관(P>0.05).P53화P73재식관린암적표체정상관(r=0.359,P=0.014).결론 P53화P73여식관린암적발생밀절상관,이차공동삼여식관린암적발전과정.
Objective To investigate the expression and correlation of P73 and PS3 proteins in esophagus squamous cell carcinoma. Methods The immunohistochemistry staining assay was conducted to detect the expression of PS3 and P73 proteins in 46 cases with squamous cell carcinoma of esophagus and 30 normal mucosa cases. The protein expressions and clinic pathological observation and the correlation between two proteins were statistically analyzed. Results The expression of P53 and P73 proteins showed differences between esophageal cancer tiksue and normal mucosa ( P = 0.007,0.008) . The expression of P53 appeared to be correlated with lymph node metastasis(P = 0.047) and gender(P =0.028),but not correlated with age, the depth of invasion , differentiation of cancer tissue, gross observation and position of the tumor( P > 0.05 ). The expression of P73 appeared to be correlated with differentiation of cancer tissue and lymph node metastasis ( P = 0. 023, 0.035), but not correlated with age, gender, the depth of invasion,gross observation and position of the tumor (P >0.05). P73 expression was positively corelated with P53 expression in squamous cell carcinoma of the esophagus ( r = 0.359 ,P = 0.014 ). Conclusion Both P73 and P53 proteins are associated with the occurrence of squamous cell carcinoma of the esophagus and participate in the development of esophagus squamous cell carcinoma.
