CAJ | 학술논문

Toll样受体(TLR) 是一类先天性跨膜受体,是病原体相关分子模式的重要识别受体.TLR通过识别病原微生物体,在炎症反应初期经由两条信号传导通路,激活免疫细胞内核因子-κB等转录因子,释放炎性介质,增强宿主防御能力,TLR过度表达导致失控性炎症反应,造成组织损伤.在急性肺损伤(ALI)及急性呼吸窘迫综合征(ARDS)的发病机制中,TLR对炎症反应的启动及介导免疫调控方面有不可忽视的作用,其中尤以TLR2和TLR4最为重要.与TLR相关的免疫调控,有望成为临床治疗ALI/ARDS的重要靶点.
Toll양수체(TLR) 시일류선천성과막수체,시병원체상관분자모식적중요식별수체.TLR통과식별병원미생물체,재염증반응초기경유량조신호전도통로,격활면역세포내핵인자-κB등전록인자,석방염성개질,증강숙주방어능력,TLR과도표체도치실공성염증반응,조성조직손상.재급성폐손상(ALI)급급성호흡군박종합정(ARDS)적발병궤제중,TLR대염증반응적계동급개도면역조공방면유불가홀시적작용,기중우이TLR2화TLR4최위중요.여TLR상관적면역조공,유망성위림상치료ALI/ARDS적중요파점.
Toll-like receptors(TLR) are a kind of vital innate transmembrane receptor and are important recognition receptors of pathogen-associated molecular pattern(PAMP).TLR activate NF-κB of immune cell which release inflammatory factor so enhance ability of host defence by two signaling pathways in initial of inflammatory reaction by recognizing PAMP.Overexpression of TLR induceloss reaction of inflammation and lead to organization injury.TLRs play a crucial role on primming of inflammatory reaction and mediating immunoregulation in pathogeny of acute lung injury(ALI) and acute respiratory distress syndrome(ARDS).TLR2 and TLR4 are considered to be most important.Immunoregulation relative to TLR is likely to be a logical therapeutic target for ALI/ARDS.