CAJ | 학술논문

目的探讨炎性反应标志物脂蛋白相关磷脂酶A2(Lp-PLA2)活性与脑供血动脉粥样硬化的关系.方法对148例脑供血动脉粥样硬化患者(脑供血动脉粥样硬化组)及40例健康体检者(对照组)的Lp-PLA2活性及传统炎性反应标志物和危险因素进行检测,并进行比较分析.结果脑供血动脉粥样硬化组Lp-PLA2活性显著高于对照组[(29.84±3.50)nmol/ (min·ml)比(19.79±2.25)nmol/(min·ml),P＜0.01)].脑供血动脉粥样硬化患者血管狭窄程度与Lp-PLA2活性呈正相关(r=0.491,P＜0.01);血管病变支数与Lp-PLA2活性呈正相关(r=0.249,P=0.026).Logistic回归分析显示,Lp-PLA2活性升高是除高敏C反应蛋白、白细胞计数等传统非特异性炎性反应标志物以外脑供血动脉粥样硬化的独立危险因素.结论 Lp-PLA2活性升高是脑供血动脉粥样硬化的独立危险因素.
목적 탐토염성반응표지물지단백상관린지매A2(Lp-PLA2)활성여뇌공혈동맥죽양경화적관계.방법 대148례뇌공혈동맥죽양경화환자(뇌공혈동맥죽양경화조)급40례건강체검자(대조조)적Lp-PLA2활성급전통염성반응표지물화위험인소진행검측,병진행비교분석.결과 뇌공혈동맥죽양경화조Lp-PLA2활성현저고우대조조[(29.84±3.50)nmol/ (min·ml)비(19.79±2.25)nmol/(min·ml),P＜0.01)].뇌공혈동맥죽양경화환자혈관협착정도여Lp-PLA2활성정정상관(r=0.491,P＜0.01);혈관병변지수여Lp-PLA2활성정정상관(r=0.249,P=0.026).Logistic회귀분석현시,Lp-PLA2활성승고시제고민C반응단백、백세포계수등전통비특이성염성반응표지물이외뇌공혈동맥죽양경화적독립위험인소.결론 Lp-PLA2활성승고시뇌공혈동맥죽양경화적독립위험인소.
Objective To estimate the relationships between lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and cerebral feeding artery athemsclemsis.Methods The blood samples were obtained from 148 atheroselerosis patients (atheroselerosis group) and 40 normal controls (control group).Activity of plasma Lp-PLA2 and traditional factors were determined.Logistic and regression model was adopted to analyze the roles of Lp-PLA2 and generally inflammatory risk factors in athemselemsis.Results Lp-PLA2 activity was significantly higher in atheroselerosis group than that in control group [(29.84±3.50)lesion number showed positive correlation with Lp-PLA2 (r=0.491,P＜0.01 and r=0.249,P=0.026).Adjusted other risk factors,Lp-PLA2 was an independent risk factor in cerebral feeding artery atherosclerosis.Conclusion Lp-PLA2,a novel inflammatory marker,is an independent risk factor of cerebral feeding artery atherosclerosis.