CAJ | 학술논문

目的探讨胸腺活化调节趋化因子(TARC)在哮喘发病中的作用及意义.方法选择同期收治的40例哮喘患者(哮喘组、急性发作期及慢性持续期各20例)及20例健康体检者(对照组),采用酶联免疫吸附试验(ELISA)法检测血清TARC、白细胞介素-4(IL-4)水平,血细胞分析仪计数外周血嗜酸性粒细胞(EOS).结果哮喘组血清TARC、IL-4水平及EOS计数均显著高于对照组,且急性期患者显著高于慢性期患者(P<0.05),三种指标间均呈正相关(P<0.05)血清TARC水平升高可能在哮喘发生和发展中起重要作用,可能机制为趋化CCR4阳性Th2细胞,使其释放大量IL-4、EOS等炎症因子.
목적 탐토흉선활화조절추화인자(TARC)재효천발병중적작용급의의.방법 선택동기수치적40례효천환자(효천조、급성발작기급만성지속기각20례)급20례건강체검자(대조조),채용매련면역흡부시험(ELISA)법검측혈청TARC、백세포개소-4(IL-4)수평,혈세포분석의계수외주혈기산성립세포(EOS).결과 효천조혈청TARC、IL-4수평급EOS계수균현저고우대조조,차급성기환자현저고우만성기환자(P<0.05),삼충지표간균정정상관(P<0.05)혈청TARC수평승고가능재효천발생화발전중기중요작용,가능궤제위추화CCR4양성Th2세포,사기석방대량IL-4、EOS등염증인자.
Objective To investigate the change and significance of thymus and activation regulated chemokine (TARC) level in serum of patients with bronchial asthma.Methods Forty patients with bronchial asthma were divided into two groups according to clinical manifestation, in which the serum level of TARC and IL-4 and 20 healthy individuals were measured respectively by ELISA. The serum EOS were counted by hemocyte analyzer.Results The levels of TARC,IL-4 and the numbers of EOS in serum of acute asthma group were all significantly higher than those of chronic and control group. The levels of TARC,IL-4 and the numbers of EOS in serum of chronic asthma group were all higher than that in controls group(P<0.05). Positive correlations were found between TARC,IL-4 and absolute numbers of EOS in serum.Conclusions TARC plays an important role in pathogenesis of asthma. The level of serum TARC may be related to the clinical manifestation of asthma. Selective recruitment positive CCR4 cells is the possible mechanism.