中国科学院研究生院学报
中國科學院研究生院學報
중국과학원연구생원학보
JOURNAL OF THE GRADUATE SCHOOL OF THE CHINESE ACADEMY OF SCIENCES
2006年
6期
842-847
,共6页
非天然折叠体%组装%疏溶剂作用%氢键制备%手性诱导%分子识别
非天然摺疊體%組裝%疏溶劑作用%氫鍵製備%手性誘導%分子識彆
비천연절첩체%조장%소용제작용%경건제비%수성유도%분자식별
foldamers%self-assembly%solvophobic interaction%hydrogen bonding%chiral induction%molecular recognition
分子折叠体是一类由非共价键稳定的、采用有序构象的寡聚物或聚合物.我们设计并合成了三类非天然的折叠体,包括:(1)由疏溶剂作用驱动的并入萘环板块的寡聚乙二醇折叠体,(2)由分子内氢键驱动的寡聚酰肼折叠体,(3)由分子内氢键驱动的并入锌卟啉板块的寡聚苯酰胺折叠体.定性和定量的研究揭示,在有机溶剂中这些折叠体可以作为非天然受体分子高效络合或识别结构匹配的有机分子和离子,并且氢键驱动的折叠体可以通过络合作用实现超分子体系的手性诱导或手性放大.
分子摺疊體是一類由非共價鍵穩定的、採用有序構象的寡聚物或聚閤物.我們設計併閤成瞭三類非天然的摺疊體,包括:(1)由疏溶劑作用驅動的併入萘環闆塊的寡聚乙二醇摺疊體,(2)由分子內氫鍵驅動的寡聚酰肼摺疊體,(3)由分子內氫鍵驅動的併入鋅卟啉闆塊的寡聚苯酰胺摺疊體.定性和定量的研究揭示,在有機溶劑中這些摺疊體可以作為非天然受體分子高效絡閤或識彆結構匹配的有機分子和離子,併且氫鍵驅動的摺疊體可以通過絡閤作用實現超分子體繫的手性誘導或手性放大.
분자절첩체시일류유비공개건은정적、채용유서구상적과취물혹취합물.아문설계병합성료삼류비천연적절첩체,포괄:(1)유소용제작용구동적병입내배판괴적과취을이순절첩체,(2)유분자내경건구동적과취선정절첩체,(3)유분자내경건구동적병입자계람판괴적과취분선알절첩체.정성화정량적연구게시,재유궤용제중저사절첩체가이작위비천연수체분자고효락합혹식별결구필배적유궤분자화리자,병차경건구동적절첩체가이통과락합작용실현초분자체계적수성유도혹수성방대.
Foldamers are linear molecules that are driven by collective noncovalent forces to fold into a conformationally ordered state in a solution or solid state. Three kinds of foldamers have been designed,synthesized and characterized, which include: ( 1 ) solvophobically-driven oligo (ethylene glycol) helical foldamers, (2) hydrogen bonded oligohydrazide foldamers and (3) hydrogen-bonded porphyrin-appended foldamers. The qualitative and quantitative investigations by NMR, UV-vis, fluorescent, and circular dichroism spectroscopy revealed that these foldamers can act as efficient receptors for discrete kinds of organic molecules and ions in different organic solvents. The supramolecular chiral induction or amplification has also been investigated for the hydrogen bonded folding systems.