国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2009年
2期
81-83
,共3页
吕东霞%田霞%鞠莹%唐伯莹%魏妮
呂東霞%田霞%鞠瑩%唐伯瑩%魏妮
려동하%전하%국형%당백형%위니
腹水%耐药性%抗生素
腹水%耐藥性%抗生素
복수%내약성%항생소
Ascites%Drug resistance%Antibiotics
目的 了解我院患者腹水样本中病原菌种类及其对抗生素的耐药情况,为临床合理应用抗生素和经验用药提供参考.方法 对我院2008年1-12月临床送检的腹水样本中分离培养的病原菌分布情况和耐药性进行回顾性分析.结果 在1653份腹水样本中共分离到病原菌151株,阳性检出率为9.13%,其中革兰阴性菌占66.23%,革兰阳性菌占25.17%,真菌占8.61%.分离到的病原菌中前4名依次为大肠埃希菌(53.64%)、表皮葡萄球菌(10.60%)、丝状真菌(7.95%)、藤黄微球菌(6.62%).革兰阴性菌以大肠埃希菌为主,其对氨苄西林、哌拉西林、氨苄西林/舒巴坦、庆大霉素的耐药率分别为78.26%、55.56%、46.67%、39.62%,对阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦耐药率较低.革兰阳性菌以表皮葡萄球菌为主,其对氨曲南和哌拉西林耐药率为100%,对万古霉素、氨苄两林、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、头孢唑林等无耐药.真菌以丝状真菌为主,感染率较高(7.95%).结论 腹水样本中病原菌呈明显多样化.大肠埃希菌是我院腹水感染的主要致病菌,对阿米卡星,哌拉西林/他唑巴坦,头孢哌酮/舒巴坦较敏感.表皮葡萄球菌对氨曲南100%耐药,对万古霉素、氨苄西林、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、头孢唑林等敏感.
目的 瞭解我院患者腹水樣本中病原菌種類及其對抗生素的耐藥情況,為臨床閤理應用抗生素和經驗用藥提供參攷.方法 對我院2008年1-12月臨床送檢的腹水樣本中分離培養的病原菌分佈情況和耐藥性進行迴顧性分析.結果 在1653份腹水樣本中共分離到病原菌151株,暘性檢齣率為9.13%,其中革蘭陰性菌佔66.23%,革蘭暘性菌佔25.17%,真菌佔8.61%.分離到的病原菌中前4名依次為大腸埃希菌(53.64%)、錶皮葡萄毬菌(10.60%)、絲狀真菌(7.95%)、籐黃微毬菌(6.62%).革蘭陰性菌以大腸埃希菌為主,其對氨芐西林、哌拉西林、氨芐西林/舒巴坦、慶大黴素的耐藥率分彆為78.26%、55.56%、46.67%、39.62%,對阿米卡星、哌拉西林/他唑巴坦、頭孢哌酮/舒巴坦耐藥率較低.革蘭暘性菌以錶皮葡萄毬菌為主,其對氨麯南和哌拉西林耐藥率為100%,對萬古黴素、氨芐兩林、哌拉西林/他唑巴坦、頭孢哌酮/舒巴坦、頭孢唑林等無耐藥.真菌以絲狀真菌為主,感染率較高(7.95%).結論 腹水樣本中病原菌呈明顯多樣化.大腸埃希菌是我院腹水感染的主要緻病菌,對阿米卡星,哌拉西林/他唑巴坦,頭孢哌酮/舒巴坦較敏感.錶皮葡萄毬菌對氨麯南100%耐藥,對萬古黴素、氨芐西林、哌拉西林/他唑巴坦、頭孢哌酮/舒巴坦、頭孢唑林等敏感.
목적 료해아원환자복수양본중병원균충류급기대항생소적내약정황,위림상합리응용항생소화경험용약제공삼고.방법 대아원2008년1-12월림상송검적복수양본중분리배양적병원균분포정황화내약성진행회고성분석.결과 재1653빈복수양본중공분리도병원균151주,양성검출솔위9.13%,기중혁란음성균점66.23%,혁란양성균점25.17%,진균점8.61%.분리도적병원균중전4명의차위대장애희균(53.64%)、표피포도구균(10.60%)、사상진균(7.95%)、등황미구균(6.62%).혁란음성균이대장애희균위주,기대안변서림、고랍서림、안변서림/서파탄、경대매소적내약솔분별위78.26%、55.56%、46.67%、39.62%,대아미잡성、고랍서림/타서파탄、두포고동/서파탄내약솔교저.혁란양성균이표피포도구균위주,기대안곡남화고랍서림내약솔위100%,대만고매소、안변량림、고랍서림/타서파탄、두포고동/서파탄、두포서림등무내약.진균이사상진균위주,감염솔교고(7.95%).결론 복수양본중병원균정명현다양화.대장애희균시아원복수감염적주요치병균,대아미잡성,고랍서림/타서파탄,두포고동/서파탄교민감.표피포도구균대안곡남100%내약,대만고매소、안변서림、고랍서림/타서파탄、두포고동/서파탄、두포서림등민감.
Objective To investigate the distribution and drug resistance of strains isolated from ascites speci-mens in patients in the sixth hospital of Shenyang in 2008, and provide some references for clinical rational drug use. Methods 1653 ascites specimens were cultured and bacterial confirmatory and antibiotic susceptibility tests were carried out. Results 151 strains were isolated from 1653 specimens of ascites, the positive rate was 9.13%. Gram-negative bacteria accounted for 66.23%, among which Escherichia coli ( E. coli )was first (53.64%). Gram-positive bacteria accounted for 25.17% and main bacteria was Staphylococcus epidermidis (10.60%), then were Micrococcus luteus (6.62 % ). Fungus accounted for 8.61%, among the fungus, Mycelial fungus accounted for 7.95 %. E. coli had high resistance rate to ampicillin(78..26%), piperacillin(55.56%), ampicillin/sulbactam(46.67%)and gentamycin (39.62%), but the resistance rate to amikacin, tazocin, cefopcrazone/sulbactam was low. Staphylococcus epidermidis had high resistance rate to aztreonam (100%), but had totally suaceptive to ampicillin, piperacillin/tazobactam, cefopcrazone/sulbactam and cefazolin. Conclusions All kinds of bacteria and fungus are isolated from ascites specimens. E. coli is the main pathogenic bacteria in the ascites specimens, and susceptive to amikacin or tazocin or cefopcrazone/ DOI: 10.3760/cma. j. issn. 1673-4149.2009.02.004sulbactam. Staphylococcus epidermidis is totally susceptive to ampicillin, piperacillin/tazobactam, cefopcrazone/sulbactam and cefazolin.
