中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
1期
80-82
,共3页
刘云飞%郑江%刘昌茂%夏安%代海涛
劉雲飛%鄭江%劉昌茂%夏安%代海濤
류운비%정강%류창무%하안%대해도
膀胱移行细胞癌%核基质蛋白22%细胞角蛋白%尿膀胱癌抗原
膀胱移行細胞癌%覈基質蛋白22%細胞角蛋白%尿膀胱癌抗原
방광이행세포암%핵기질단백22%세포각단백%뇨방광암항원
Bladder transitional cell carcinoma%Nuclear matrix protein 22%Cytokeratins%Urinary bladder cancer antigen
目的 探讨核基质蛋白22(NMP22)及尿膀胱癌抗原(UBC)的检测用于早期诊断膀胱移行细胞癌(BTCC)的可行性及影响因素.方法 膀胱移行细胞癌患者60例,泌尿系良性疾病患者25例,健康对照组20名,采用酶联免疫(ELISA)方法检测尿NMP22及UBC.膀胱镜检查前取尿样分别进行NMP22、UBC和脱落细胞学检测,分析比较3种方法的敏感性、特异性、阳性和阴性预测价值.结果 以大于正常对照组尿液NMP22水平上限10 U/ml为NMP22阳性界值,以12μg/L为UBC诊断膀胱移行细胞癌的临界值时,NMP22和UBC诊断膀胱移行细胞癌的敏感性分别为88.3%和86.7%,与脱落细胞学(40.0%)比较,差异均有统计学意义(P均<0.01),3种方法诊断膀胱移行细胞癌的特异性分别为80.0%、84.0%和92.0%,阳性预测值分别为91.4%、92.9%和92.3%,阴性预测值分别为74.1%、72.4%和38.9%.结论 尿NMP22和UBC检测技术简单,有较高的敏感性和特异性,可作为早期诊断膀胱移行细胞癌的肿瘤标记物.
目的 探討覈基質蛋白22(NMP22)及尿膀胱癌抗原(UBC)的檢測用于早期診斷膀胱移行細胞癌(BTCC)的可行性及影響因素.方法 膀胱移行細胞癌患者60例,泌尿繫良性疾病患者25例,健康對照組20名,採用酶聯免疫(ELISA)方法檢測尿NMP22及UBC.膀胱鏡檢查前取尿樣分彆進行NMP22、UBC和脫落細胞學檢測,分析比較3種方法的敏感性、特異性、暘性和陰性預測價值.結果 以大于正常對照組尿液NMP22水平上限10 U/ml為NMP22暘性界值,以12μg/L為UBC診斷膀胱移行細胞癌的臨界值時,NMP22和UBC診斷膀胱移行細胞癌的敏感性分彆為88.3%和86.7%,與脫落細胞學(40.0%)比較,差異均有統計學意義(P均<0.01),3種方法診斷膀胱移行細胞癌的特異性分彆為80.0%、84.0%和92.0%,暘性預測值分彆為91.4%、92.9%和92.3%,陰性預測值分彆為74.1%、72.4%和38.9%.結論 尿NMP22和UBC檢測技術簡單,有較高的敏感性和特異性,可作為早期診斷膀胱移行細胞癌的腫瘤標記物.
목적 탐토핵기질단백22(NMP22)급뇨방광암항원(UBC)적검측용우조기진단방광이행세포암(BTCC)적가행성급영향인소.방법 방광이행세포암환자60례,비뇨계량성질병환자25례,건강대조조20명,채용매련면역(ELISA)방법검측뇨NMP22급UBC.방광경검사전취뇨양분별진행NMP22、UBC화탈락세포학검측,분석비교3충방법적민감성、특이성、양성화음성예측개치.결과 이대우정상대조조뇨액NMP22수평상한10 U/ml위NMP22양성계치,이12μg/L위UBC진단방광이행세포암적림계치시,NMP22화UBC진단방광이행세포암적민감성분별위88.3%화86.7%,여탈락세포학(40.0%)비교,차이균유통계학의의(P균<0.01),3충방법진단방광이행세포암적특이성분별위80.0%、84.0%화92.0%,양성예측치분별위91.4%、92.9%화92.3%,음성예측치분별위74.1%、72.4%화38.9%.결론 뇨NMP22화UBC검측기술간단,유교고적민감성화특이성,가작위조기진단방광이행세포암적종류표기물.
Objective To assess the feasibility of nuclear matrix protein 22(NMP22)and urinary bladder cancer,antigen (UBC) for the early diagnosis of bladder transitional cell carcinoma and its influencing factors.Methotis 105 subjects,including 60 patients of bladder cancer,25 patients of urological benign disease and 20 normal (healthy)individuals were enrolled in this study.Urine NMP22 and UBC wag assessed by enzyme-linked immunosorbent assay(ELISA).Urine NMP22 and UBC as well as exfoliocytology were conducted for the purpose to compare the sensitivity,specificity,positive and negative predictive value of these three ways.Results The sensitivity of NMP22(88.3%)and UBC(86.7%)were significantly better than exfolioeytology(40.0%,P<0.01).The specificity of NMP22,UBC and exfoliocytology were 80.0%,84.0%and 92.0%,respectively, the positive predictive values were 91.4%,92.9%and 92.3%,and the negative predictive values were 74.1%.72.4%and 38.9%.Conclusions NMP22 and UBC are sensitive,specific,simple,feasible and noninvasive diagnostic markers for the early detection of urinary bladder transitional cell cancer.
