中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2010年
4期
240-243
,共4页
树突状细胞%炎症性肠病%黏膜免疫%免疫耐受
樹突狀細胞%炎癥性腸病%黏膜免疫%免疫耐受
수돌상세포%염증성장병%점막면역%면역내수
Dendritic cells%Inflammatory bowel disease%Mucosal immunity%Immune tolerance
炎症性肠病可能是遗传和环境因素共同作用导致肠道黏膜对肠道正常菌群免疫反应失常而引起的慢性非特异性炎症.树突状细胞在抗原富集的肠道环境中起着调节免疫应答的重要作用,既能启动免疫应答,又能诱导免疫耐受.这种调节功能缺陷可能导致炎症性肠病.本文就相关方面的研究进展进行综述.
炎癥性腸病可能是遺傳和環境因素共同作用導緻腸道黏膜對腸道正常菌群免疫反應失常而引起的慢性非特異性炎癥.樹突狀細胞在抗原富集的腸道環境中起著調節免疫應答的重要作用,既能啟動免疫應答,又能誘導免疫耐受.這種調節功能缺陷可能導緻炎癥性腸病.本文就相關方麵的研究進展進行綜述.
염증성장병가능시유전화배경인소공동작용도치장도점막대장도정상균군면역반응실상이인기적만성비특이성염증.수돌상세포재항원부집적장도배경중기착조절면역응답적중요작용,기능계동면역응답,우능유도면역내수.저충조절공능결함가능도치염증성장병.본문취상관방면적연구진전진행종술.
Inflammatory bowel diseases (IBD) possibly lie in a dysregulated response of the intestinal mucosal immune system towards intestinal microflora under a combined action of genetic and environmental factors.Mucosal dendritic cells are assumed to play key roles in regulating immune responses in the antigen-riched intestinal environment, either by initiating immune responses or by maintaining tolerance. Defects in this regulation are supposed to lead to IBD. This paper reviews the recent research advances in the relationship between IBD and dendritic cells.