CAJ | 학술논문

目的通过对相关文献的荟萃分析,评价低剂量螺旋CT(LDCT)在高危人群早期肺癌筛查中的作用.方法利用关键词在PubMed、EBSCO、Cochrane等数据库中进行文献查找,根据制定的纳入标准和排除标准对文献进行筛选,最后纳入数据,利用统计软件进行数据分析并得出统计结果.结果纳入10个随机对照研究的数据.与胸部X线(CXR)检查及无检查的对照组相比,LDCT组的肺癌检出率较对照组的优势比(OR)为3.705(95％ CI3.527～3.891).亚组分析中,LDCT对Ⅰ期肺癌的检测较对照组高了4.464倍(95％CI2.860～6.969),腺癌的检出率在LDCT组比对照组高了4.652倍(95％ CI2.877 ～7.522).结论 LDCT对肺癌尤其是Ⅰ期肺癌、腺癌具有较高的检出率.
목적 통과대상관문헌적회췌분석,평개저제량라선CT(LDCT)재고위인군조기폐암사사중적작용.방법 이용관건사재PubMed、EBSCO、Cochrane등수거고중진행문헌사조,근거제정적납입표준화배제표준대문헌진행사선,최후납입수거,이용통계연건진행수거분석병득출통계결과.결과 납입10개수궤대조연구적수거.여흉부X선(CXR)검사급무검사적대조조상비,LDCT조적폐암검출솔교대조조적우세비(OR)위3.705(95％ CI3.527～3.891).아조분석중,LDCT대Ⅰ기폐암적검측교대조조고료4.464배(95％CI2.860～6.969),선암적검출솔재LDCT조비대조조고료4.652배(95％ CI2.877 ～7.522).결론 LDCT대폐암우기시Ⅰ기폐암、선암구유교고적검출솔.
Objective To explore the values of low-dose computed tomography(LDCT)in the screening of high-risk populations for early lung cancer through a meta-analysis of the relevant literature.Methods PubMed,EBSCO,Cochrane and other databases were searched with key words.And the studies were selected by the inclusion and exclusion criteria.The baseline data were collected and analyzed by statistical software.Results Ten random controlled trials(RCTs)were selected.Compared to the chest X ray(CXR)screening and no screening controls,LDCT screening had an odds ratio(OR)of 3.705,95％ CI 3.527-3.891.And in the subgroup analysis,a higher number of stage Ⅰ lung cancer was detected(OR4.464,95％ CI 2.860-6.969)by LDCT.Moreover,LDCT screening showed an increased detection of adenocarcinoma in lung cancer(OR 4.652,95％ CI 2.877-7.522).Conclusion LDCT is superior to CXR in the early detection of lung cancer,especially stage Ⅰ and adenocarcinoma.