浙江大学学报(医学版)
浙江大學學報(醫學版)
절강대학학보(의학판)
JOURNAL OF ZHEJIANG UNIVERSITY(MEDICAL SCIENCES)
2001年
2期
70-72,89
,共4页
王连聪%郑树%魏启春%束美宝%项建杰
王連聰%鄭樹%魏啟春%束美寶%項建傑
왕련총%정수%위계춘%속미보%항건걸
鼻咽肿瘤/药物疗法%新蝶呤/治疗应用%抗原,CD4/分析%抗原,CD8/分析%预后
鼻嚥腫瘤/藥物療法%新蝶呤/治療應用%抗原,CD4/分析%抗原,CD8/分析%預後
비인종류/약물요법%신접령/치료응용%항원,CD4/분석%항원,CD8/분석%예후
目的:探讨血清新蝶呤、sCD4及sCD8分子水平和鼻咽癌的关系及临床意义。方法:采用ELISA方法检测54例初治鼻咽低分化鳞癌治疗前、后及32例健康成人的血清新蝶呤、sCD4与sCD8分子浓度。结果:鼻咽癌血清新蝶呤、sCD4及sCD8浓度高于健康对照组(P<0.001)。不同TNM分期血清新蝶呤、sCD4及sCD8水平无差异(P>0.05);无淋巴结转移者血清新蝶呤低于有淋巴结转移者(P<0.05)。治疗后新蝶呤、sCD4与sCD8水平比治疗前明显降低(P<0.01),仍比对照组高(P<0.01);治疗后6月肿瘤全消者继续保持在较低水平,肿瘤残留者则回升到治疗前水平(P<0.01和0.05)。结论:血清新蝶呤、sCD4与sCD8分子水平检测可作为鼻咽癌病情评估、疗效监测及随访的客观指标。
目的:探討血清新蝶呤、sCD4及sCD8分子水平和鼻嚥癌的關繫及臨床意義。方法:採用ELISA方法檢測54例初治鼻嚥低分化鱗癌治療前、後及32例健康成人的血清新蝶呤、sCD4與sCD8分子濃度。結果:鼻嚥癌血清新蝶呤、sCD4及sCD8濃度高于健康對照組(P<0.001)。不同TNM分期血清新蝶呤、sCD4及sCD8水平無差異(P>0.05);無淋巴結轉移者血清新蝶呤低于有淋巴結轉移者(P<0.05)。治療後新蝶呤、sCD4與sCD8水平比治療前明顯降低(P<0.01),仍比對照組高(P<0.01);治療後6月腫瘤全消者繼續保持在較低水平,腫瘤殘留者則迴升到治療前水平(P<0.01和0.05)。結論:血清新蝶呤、sCD4與sCD8分子水平檢測可作為鼻嚥癌病情評估、療效鑑測及隨訪的客觀指標。
목적:탐토혈청신접령、sCD4급sCD8분자수평화비인암적관계급림상의의。방법:채용ELISA방법검측54례초치비인저분화린암치료전、후급32례건강성인적혈청신접령、sCD4여sCD8분자농도。결과:비인암혈청신접령、sCD4급sCD8농도고우건강대조조(P<0.001)。불동TNM분기혈청신접령、sCD4급sCD8수평무차이(P>0.05);무림파결전이자혈청신접령저우유림파결전이자(P<0.05)。치료후신접령、sCD4여sCD8수평비치료전명현강저(P<0.01),잉비대조조고(P<0.01);치료후6월종류전소자계속보지재교저수평,종류잔류자칙회승도치료전수평(P<0.01화0.05)。결론:혈청신접령、sCD4여sCD8분자수평검측가작위비인암병정평고、료효감측급수방적객관지표。
Objective:To evaluate the relationship betwe en serum levels of neopterin and sCD4 & sCD8 antigens and nasopharyngeal carcino ma and its clinical significance.Methods:The serum levels of neopter in and sCD4 & sCD8 antigens were determined in 54 patients with nasopharyngeal c arc inoma(NPC group) and 32 healthy adults(normal group) by ELISA.Results:The serum levels of neopterin and sCD4 & sCD8 antigens in NPC group were signi ficantly higher than those in normal group(P<0.001).The serum levels of neo pterin and sCD4 & sCD8 antigens were not related to UICC-TNM stages(P>0.05 ).The serum neopterin levels in patients without lymph node metastasis were lowe r than those with metastasis(P<0.05).The serum levels of neopterin and sCD4 & sCD8 antigens decreased significantly after raditoherapy(P<0.01).C onclusion:The measurement of the serum levels of neopterin and sCD4 & sCD8 antigens in patients with nasopha ryngeal carcinoma reflects disease status and may be a useful objective index to evaluate cellular immunological functions and curative effects and prognosis.