CAJ | 학술논문

干细胞抗原1 (Sca-1) 是干细胞的一种重要表面标记物,体内许多干细胞都表达Sca-1.同样,心肌干细胞也表达Sca-1.目前研究发现,Sca-1~+心肌干细胞能够分化为心肌细胞,对心肌梗死后心室重构与心肌再生具有明显作用,能够促进心脏的修复.因此,Sca-1~+心肌干细胞有可能使心肌梗死的临床治疗取得实质性的进展.现综述了Sca-1~+心肌干细胞的来源、分化、作用等方面.
간세포항원1 (Sca-1) 시간세포적일충중요표면표기물,체내허다간세포도표체Sca-1.동양,심기간세포야표체Sca-1.목전연구발현,Sca-1~+심기간세포능구분화위심기세포,대심기경사후심실중구여심기재생구유명현작용,능구촉진심장적수복.인차,Sca-1~+심기간세포유가능사심기경사적림상치료취득실질성적진전.현종술료Sca-1~+심기간세포적래원、분화、작용등방면.
Stem cell antigen-1 (Sca-1) is an important surface marker for stem cells;cardiac myocytes, and other somatic stem cells express Sca-1. Recently, a number of reports have suggested that Sca-1~+ cardiac stem cells were capable of differentiating into cardiac myocytes, which were significantly contributing to post myocardial infarction (post-MI) left ventricular remodeling and myocardium regeneration, and which could promote cardiac repair. Accordingly, Sca-1~+ cardiac stem cells might lead to clinically useful therapies for myocardial infarction. This paper reviews research done on the differentiation and role of Sca-1~+ cardiac stem cells.