CAJ | 학술논문

目的:了解美沙酮维持治疗(MMT)对海洛因依赖者情绪状态的影响,为维持治疗提供指导.方法:使用抑郁自评量表(CES-D),分别对131例参加美沙酮维持治疗一年以上的海洛因依赖者及120例来我院进行自愿戒毒的海洛因依赖者(对照组)急性脱毒前、后予以问卷调查,将两组人群的CES-D总评分及各单项评分予以比较、分析.结果: 64.1%的美沙酮维持治疗者肯定有抑郁症状,对照组抑郁症状检出率为64.2%,两组抑郁症状患病率差异无统计学意义(P＞0.05).美沙酮维持治疗组常见抑郁症状依次为无愉快感(57.3%)、空虚感(56.5%)、自卑感(51.9%)、绝望感(45.0%),而对照组依次为自卑感(64.2%)、绝望感(59.2%)、无愉快感(55.8%)、空虚感(52.5%);对照组脱毒前、后抑郁症状改变差异无统计学意义(P＞0.05);与对照组相比(治疗前后),MMT能显著改善自卑感、绝望感等抑郁症状,差异有统计学意义(P＜0.05),但对无愉快感、空虚感无改善.结论:美沙酮维持治疗对抑郁状态总体无改善作用,但一定程度上具有部分改善抑郁情绪不同症状的作用,如降低患者的自卑感和绝望感.在治疗过程中,必须高度重视美沙酮维持治疗者的情绪状态以提高MMT治疗效果.
목적:료해미사동유지치료(MMT)대해락인의뢰자정서상태적영향,위유지치료제공지도.방법:사용억욱자평량표(CES-D),분별대131례삼가미사동유지치료일년이상적해락인의뢰자급120례래아원진행자원계독적해락인의뢰자(대조조)급성탈독전、후여이문권조사,장량조인군적CES-D총평분급각단항평분여이비교、분석.결과: 64.1%적미사동유지치료자긍정유억욱증상,대조조억욱증상검출솔위64.2%,량조억욱증상환병솔차이무통계학의의(P＞0.05).미사동유지치료조상견억욱증상의차위무유쾌감(57.3%)、공허감(56.5%)、자비감(51.9%)、절망감(45.0%),이대조조의차위자비감(64.2%)、절망감(59.2%)、무유쾌감(55.8%)、공허감(52.5%);대조조탈독전、후억욱증상개변차이무통계학의의(P＞0.05);여대조조상비(치료전후),MMT능현저개선자비감、절망감등억욱증상,차이유통계학의의(P＜0.05),단대무유쾌감、공허감무개선.결론:미사동유지치료대억욱상태총체무개선작용,단일정정도상구유부분개선억욱정서불동증상적작용,여강저환자적자비감화절망감.재치료과정중,필수고도중시미사동유지치료자적정서상태이제고MMT치료효과.
Objective:To explore the effect of methadone maintenance treatment(MMT) on the emotional status of heroin dependent patients with heroin dependence and provide guidance for MMT.Methods: Patients including 131 cases on MMT over a year and 120 inpatients(as control) on detoxification voluntarily were assessed by CES-D. The results were analyzed and compared. Results:Obvious depression was discovered in 64.1% of MMT patients and 64.2% of the controls and no significant difference was observed between the two groups (P>0.05). The common depression symptoms in MMT group were loss of enjoyment(57.3%),feeling hollow(56.5%),reduced self-esteem(51.9%) and despairing(45.0%);while in the control group were reduced self-esteem(64.2%), despairing(59.2%), loss of enjoyment(55.8%) and feeling hollow(52.5%). No significant changes in the common depression symptoms were found after detoxification in the control group(P>0.05). Compared with the control group(pre and post defoxification), MMT patients improved in the depression symptoms such as reduced self-esteem and despairing,showing statistical significance (P<0.05/P<0.01), no changes had taken place in loss of enjoyment and feeling hollow. Conclusion: In general,MMT is not able to change the depression status of heroin dependent patients,but can partly lessen some depression symptoms such as reduced self-esteem and despairing,which suggests that during the process of MMT,attention should be paid to the emotional status of MMT patients so as to improve MMT efficacy.