CAJ | 학술논문

改善胰岛素敏感性对防治2型糖尿病(T2DM)有重要意义.我国中医药治疗糖尿病效果显著但机制尚不甚清楚,本课题组从改善胰岛素敏感性的角度入手,先后通过药物筛选、细胞和动物实验3个部分研究中药大黄单体成分--大黄酸对糖尿病的治疗作用,其机制可能与上调机体外周组织的过氧化物酶体增殖物活化受体(PPAR)-慵捌咸烟亲说鞍?GLUT)表达,从而促进外周组织葡萄糖摄取并改善机体胰岛素敏感性有关.本文将分别对这3部分实验内容进行介绍并就大黄酸改善胰岛素敏感性的作用机制展开讨论.
개선이도소민감성대방치2형당뇨병(T2DM)유중요의의.아국중의약치료당뇨병효과현저단궤제상불심청초,본과제조종개선이도소민감성적각도입수,선후통과약물사선、세포화동물실험3개부분연구중약대황단체성분--대황산대당뇨병적치료작용,기궤제가능여상조궤체외주조직적과양화물매체증식물활화수체(PPAR)-용팔함연친설안?GLUT)표체,종이촉진외주조직포도당섭취병개선궤체이도소민감성유관.본문장분별대저3부분실험내용진행개소병취대황산개선이도소민감성적작용궤제전개토론.
The improvement of insulin sensitivity plays an important role in the treatment of type 2 diabetes mellitus(T2DM).Many kinds of Chinese herbs are proved to be effective for T2DM treatment,but the mechaJlisms are still unclear.Our series studies show rhein may improve insulin sensitivity through the activation of peroxisome proliferator activated reeeptor γ(PPARγ)and the up-regulation of glucose transporter (GLUT) expression.This article introduces the series studies including PPARγ activators screening,vitro and vivo studies and discusses the mechanism of rhein in improving insulin sensitivity.