CAJ | 학술논문

本文以高效液相仪检测37例脑囊虫患者脑脊液及血浆的吡喹酮浓度,服药剂量为顿服40mg/kg(共7例)、13.3mg/kg(28例),另2例为总剂量120mg/kg,三日分服,顿服及末次服药后2～2 1/4小时抽取标本.三种方法服药后的平均血浆浓度分别为2.2075、0.8599及1.3550μg/ml,平均脑脊液浓度分别为0.2328、0.1657及0.315μg/ml.脑脊液浓度相当于血浓度的10.54～23.24%.本文又以测算cT病灶面积的方法来评估疗效,16例脑囊虫病患者以总量120mg/kg,三日分服,治后病灶面积减少了90.76%.
본문이고효액상의검측37례뇌낭충환자뇌척액급혈장적필규동농도,복약제량위돈복40mg/kg(공7례)、13.3mg/kg(28례),령2례위총제량120mg/kg,삼일분복,돈복급말차복약후2～2 1/4소시추취표본.삼충방법복약후적평균혈장농도분별위2.2075、0.8599급1.3550μg/ml,평균뇌척액농도분별위0.2328、0.1657급0.315μg/ml.뇌척액농도상당우혈농도적10.54～23.24%.본문우이측산cT병조면적적방법래평고료효,16례뇌낭충병환자이총량120mg/kg,삼일분복,치후병조면적감소료90.76%.
The CSF and plasma concentration of praziquantel(P) was determined with high performance liquid chromatographio (HPLC) method in 37 cases of oysticercosis cellulosae.CSF and blood specimens were taken 2 to 2 1/4 hour after adminisbration of P.A single dose of 40 mg/kg was given in 7 cases.the CSF and plasma concentration Was 0.2328±0.1333 and 2.2075±1.1366/μg/ml respectively.A single dose of 13.3 mg/kg was given in 28 cases,the CSF and plasma concentration was 0.1657±0.0960 and 0.8599±0.5759/μg/ml respectively.40 mg/kg of praziquantal was administered for the first day in a single dose.and then followed by 13.3 mg/kg 3 times daily for the second and third day in 2 cases.CSF and blood samples were taken 2 to 2 1/4 hour after the last dose.The drug concentration of the CSF and plasma was 0.315 and 1.3550μg/ml respeotively.The CSF/plasma ratio was 10.54% to 23.24%.Sixteen cases with cerebral oysticercosis were treated with P.The dosage Was 13.3 mg/kg 3 times daily for 3 days.The total number of cysts on CT scans had been.decreased from 34 to 11.and the size of cysts was reduced by 90.76%.