CAJ | 학술논문

糖尿病视网膜病变(DR)是一种与血糖水平、病程长短以及遗传与环境因素相互作用所致的复杂疾病,其相关或易感基因的研究在近年来非常活跃.DR的相关候选基因包括醛糖还原酶基因、血管内皮生长因子基因、血管紧张素转换酶基因、一氧化氮合酶基因、非酶糖基化终末产物受体基因等.DR是多基因作用的疾病,而每个基因存在不同的多态性.准确把握基因在DR发生发展过程中的作用机制及其表达的差异性,对其早期诊断、防治DR的发生发展及开发新的诊疗手段具有重要意义.本文就有关DR相关基因的研究现状及进展进行综述.
당뇨병시망막병변(DR)시일충여혈당수평、병정장단이급유전여배경인소상호작용소치적복잡질병,기상관혹역감기인적연구재근년래비상활약.DR적상관후선기인포괄철당환원매기인、혈관내피생장인자기인、혈관긴장소전환매기인、일양화담합매기인、비매당기화종말산물수체기인등.DR시다기인작용적질병,이매개기인존재불동적다태성.준학파악기인재DR발생발전과정중적작용궤제급기표체적차이성,대기조기진단、방치DR적발생발전급개발신적진료수단구유중요의의.본문취유관DR상관기인적연구현상급진전진행종술.
Diabetic retinopathy (DR) is a complex disease which is caused by the interaction of blood glucose levels,duration of diabetes,and genetic and environmental factors.The research of its related genes or susceptibility genes is very active in the recent years.These candidate genes include aldose reductase gene (AR),vascular endothelial growth factor gene (VEGF),angiotensin-convening enzyme gene (ACE),inducible and constitutive nitric oxide synthases gene (NOS),receptor for advanced glycation endproducts gene (RAGE) and so on.DR is a disease of the role of multiple genes,and therefore there is different polymorphisms in each gene.It is very important for us to accurately understand the mechanism of the difference expression of gene during the occurrence and development of DR for the early diagnosis and prevention of DR.The current research advance in DR relevant gene is reviewed in this article.