CAJ | 학술논문

目的探讨p57kip2免疫组织化学染色鉴别葡萄胎和流产伴绒毛水肿的意义.方法观察组织学伴有绒毛水肿的诊断病例58例(完全性葡萄胎18例、部分性葡萄胎19例、流产伴绒毛水肿11例、不明确流产伴绒毛水肿和葡萄胎分类的10例)以及正常胎盘3例的p57kip2免疫组织化学染色表达情况.结果正常绒毛、部分性葡萄胎、流产伴绒毛水肿显示p57kip2阳性,核表达于细胞滋养细胞和绒毛问质细胞,而完全性葡萄胎在滋养细胞和绒毛问质细胞上显示阴性.根据组织学形态诊断分类与结合p57kip2诊断结果比较分析,在p57kip2染色的敏感度96%(46/48).结论 p57kip2免疫组织化学染色在鉴别葡萄胎和流产伴绒毛水肿是一个有价值的诊断方法,是葡萄胎敏感和特异的标记.
목적 탐토p57kip2면역조직화학염색감별포도태화유산반융모수종적의의.방법 관찰조직학반유융모수종적진단병례58례(완전성포도태18례、부분성포도태19례、유산반융모수종11례、불명학유산반융모수종화포도태분류적10례)이급정상태반3례적p57kip2면역조직화학염색표체정황.결과 정상융모、부분성포도태、유산반융모수종현시p57kip2양성,핵표체우세포자양세포화융모문질세포,이완전성포도태재자양세포화융모문질세포상현시음성.근거조직학형태진단분류여결합p57kip2진단결과비교분석,재p57kip2염색적민감도96%(46/48).결론 p57kip2면역조직화학염색재감별포도태화유산반융모수종시일개유개치적진단방법,시포도태민감화특이적표기.
Objective To study the signification of p57kip2 immunostaining to distinguish molar gestations from hydropic abortions.Methods To observe the p57kip2 immunohistochemical expression in 58 cases of histological hydropic villi which were divided into complete mole(18 cases) ,partial mole(19 cases),hydropic abortion(11 cases)and undetermined hydropic abortion or molar gestations(10 cases) and in 3 normal placentas.Results Normal villi,partial mole and hydropic abortions show positive staining for p57kip2, which expressed in the nuclei of cytotrophoblast and villous mesenchyme,and complete moles show complete absence of staining in the cytotrophoblast and villous mesenchyme.According to the comparison of the diagnosis based on morphology and the one based on p57kip2 stai-ning,the later whose sensitivity is 96% (46/48) confirmed the earlier diagnosis in 58 cases studied and the later conformed to the earlier very well.Conclusion The immunohistochemical staining for p57kip2 is a valuable diagnostic mean to distinguish molar gestations from hydropic abortions and is a sensitive and specific marker for the diagnosis of complete mole.