中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
1期
62-63
,共2页
李恩君%马文群%朱海生%吕宝芳%武来兴%张桂东
李恩君%馬文群%硃海生%呂寶芳%武來興%張桂東
리은군%마문군%주해생%려보방%무래흥%장계동
大肠癌%血管内皮生长因子%微血管密度%免疫组化
大腸癌%血管內皮生長因子%微血管密度%免疫組化
대장암%혈관내피생장인자%미혈관밀도%면역조화
Colorectal carcinoma%Vascular endothelial grouth factor%Micro vessel density%Immunohistochemistry
目的 探讨大肠癌组织中血管内皮生长因子(VEGF)与淋巴结转移的关系.方法 采用免疫组化方法检测40份大肠癌组织中VEGF的表达,采用CD34标记计数肿瘤组织微血管密度(MVD),分析VEGF与大肠癌淋巴结转移的关系,采用x2检验和Spearman等级相关分析对相应资料进行分析.结果 40例大肠癌患者淋巴结转移24例,MVD为40.65±11.80,VEGF阳性21例(87.5%);无转移16例,MVD为25.02±11.52,VEGF阳性4例(25.0%),有无淋巴结转移组MVD和VEGF阳性率比较差异均有统计学意义(t=-4.138,x2=16.00,P均<0.01).40份大肠癌组织中VEGF蛋白表达阳性25例,MVD为41.33±11.61;VEGF阴性15例,MVD为22.84±8.88,组间比较差异有统计学意义(t=5.301,P<0.05).大肠癌组织中VEGF的表达与MVD呈正相关(rs=0.539,P<0.05).结论 VEGF可能促进大肠癌的血管生成,进而促进大肠癌的转移.
目的 探討大腸癌組織中血管內皮生長因子(VEGF)與淋巴結轉移的關繫.方法 採用免疫組化方法檢測40份大腸癌組織中VEGF的錶達,採用CD34標記計數腫瘤組織微血管密度(MVD),分析VEGF與大腸癌淋巴結轉移的關繫,採用x2檢驗和Spearman等級相關分析對相應資料進行分析.結果 40例大腸癌患者淋巴結轉移24例,MVD為40.65±11.80,VEGF暘性21例(87.5%);無轉移16例,MVD為25.02±11.52,VEGF暘性4例(25.0%),有無淋巴結轉移組MVD和VEGF暘性率比較差異均有統計學意義(t=-4.138,x2=16.00,P均<0.01).40份大腸癌組織中VEGF蛋白錶達暘性25例,MVD為41.33±11.61;VEGF陰性15例,MVD為22.84±8.88,組間比較差異有統計學意義(t=5.301,P<0.05).大腸癌組織中VEGF的錶達與MVD呈正相關(rs=0.539,P<0.05).結論 VEGF可能促進大腸癌的血管生成,進而促進大腸癌的轉移.
목적 탐토대장암조직중혈관내피생장인자(VEGF)여림파결전이적관계.방법 채용면역조화방법검측40빈대장암조직중VEGF적표체,채용CD34표기계수종류조직미혈관밀도(MVD),분석VEGF여대장암림파결전이적관계,채용x2검험화Spearman등급상관분석대상응자료진행분석.결과 40례대장암환자림파결전이24례,MVD위40.65±11.80,VEGF양성21례(87.5%);무전이16례,MVD위25.02±11.52,VEGF양성4례(25.0%),유무림파결전이조MVD화VEGF양성솔비교차이균유통계학의의(t=-4.138,x2=16.00,P균<0.01).40빈대장암조직중VEGF단백표체양성25례,MVD위41.33±11.61;VEGF음성15례,MVD위22.84±8.88,조간비교차이유통계학의의(t=5.301,P<0.05).대장암조직중VEGF적표체여MVD정정상관(rs=0.539,P<0.05).결론 VEGF가능촉진대장암적혈관생성,진이촉진대장암적전이.
Objective To investigate the correlation between the expression of VEGF and the lymph node metastasis of colorectal carcinoma.Methods VEGF was detected by immunohistochemistry in 24 cases of colorectal carcinoma with lymph node metastasis and 16 case of colorectal carcinoma without lymph node metastasis.CD34 was used as a marker to evaluate the MVD.All the data were analyzed using 10.1 statistical package.The comparison was performed by x2 test and Spearman rank correlation analysis.The level of significance is α =0.05.Results in the 40 cases of colorectal carcinoma,24 cases encountered lymph node metastasis with an MVD (40.65 ± 11.80) and 21 cases were VEGF positive (87.5%).In the 16 cases without metastasis,the MVD was (25.02 ± 11.52) and 4 cases were VEGF positive (25.0%).MVD and VEGF were significantly different between thecases with lymph node metastasis and those without (t =-4.138,x2 =16.00,P <0.01 ).In the 40 cases,there were 25 cases with positive VEGF with an MVD (41.33 ± 11.61 ) and 15 cases with negative VEGF with and MVD (22.84 ±8.88).The difference between the cases with positive VEGF and those with negative VEGF (t =5.301,P <0.05 ).VEGF level was positive correlated with MVD in the colon cancer ( rs =0.539,P < 0.05 ).Conclusion VEGF may play a role in promoting the lymph node metastasis of colorectal carcinoma