CAJ | 학술논문

目的探讨雷贝拉唑-莫西沙星-呋喃唑酮三联一周疗法治疗初治失败的幽门螺杆菌感染的疗效.方法 90例患者随机分为观察组45例和治疗组45例.观察组予雷贝拉唑+莫西沙星+呋喃唑酮三联疗法治疗；对照组予奥美拉唑+克拉霉素+甲硝唑三联疗法治疗.两组均治疗7d,观察其幽门螺杆菌根除率.结果观察组和对照组的幽门螺杆菌根除率分别为88.89％和68.89％,两组根除率比较差异有统计学意义(P＜0.05).结论雷贝拉唑-莫西沙星-呋喃唑酮三联一周疗法可作为抗幽门螺杆菌感染的选择,尤其适合于在应用其他抗生素耐药情况下使用.
목적 탐토뢰패랍서-막서사성-부남서동삼련일주요법치료초치실패적유문라간균감염적료효.방법 90례환자수궤분위관찰조45례화치료조45례.관찰조여뢰패랍서+막서사성+부남서동삼련요법치료；대조조여오미랍서+극랍매소+갑초서삼련요법치료.량조균치료7d,관찰기유문라간균근제솔.결과 관찰조화대조조적유문라간균근제솔분별위88.89％화68.89％,량조근제솔비교차이유통계학의의(P＜0.05).결론 뢰패랍서-막서사성-부남서동삼련일주요법가작위항유문라간균감염적선택,우기괄합우재응용기타항생소내약정황하사용.
Objective To observe the effect and safety of one week triple therapy of moxifloxacin combined with rabeprazole and furazolidone for initial treatment failure Helicobacter pylori (Hp) eradication.Methods Ninety patients with Hp infection suffering from peptic ulcer were divided into observation group (45 cases) and treatment group (45 cases).The observation group treated by moxifloxacin combined with rabeprazole and furazolidone,the treatment group treated by omeprazole combined with clarithromycin and metronidazole.The course of both treatments was 7 days.After the treatment,the Hp eradication were observed.Results After 7 days of treatment,the total effect rate of improvement was 88.89％ for observation group and 68.89％ for treatment group,respectively,the difference was significant (P ＜ 0.05 ).Conclusions One week triple therapy of moxifloxacin combined with rabeprazole and furazolidone is the first choice for Hp eradication.Especially for the case in the application of the use of other antibiotic resistance.