中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
16期
48-51
,共4页
妊娠%中性粒细胞激活肽-78%睡眠呼吸暂停综合征%巨噬细胞移动抑制因子
妊娠%中性粒細胞激活肽-78%睡眠呼吸暫停綜閤徵%巨噬細胞移動抑製因子
임신%중성립세포격활태-78%수면호흡잠정종합정%거서세포이동억제인자
Pregnancy%Epithelial neutrophil-activing peptide-78%Sleep apnea syndromes%Macrophage migration inhibitory factor
目的 探讨妊娠合并阻塞性睡眠呼吸暂停低通气综合征( OSAHS)与血清中性粒细胞激活肽-78(ENA-78)和巨噬细胞移动抑制因子(MIF)的相关性及其意义.方法 选择妊娠合并OSAHS患者102例和正常妊娠36例行标准多导睡眠呼吸监测系统监测记录呼吸暂停低通气指数(AHI)；并根据AHI分为轻度OSAHS组36例,中度OSAHS组34例和重度OSAHS组32例.采用酶联免疫(ELISA)法检测血清ENA-78和MIF含量.结果 OSAHS合并高血压组AHI、MAP、ENA-78和MIF含量明显高于单纯OSAHS组(t=13.46,11.65,12.47,13.52,P均＜0.01)和正常妊娠组(t=16.72,15.31,16.35,17.43,P均＜0.01),单纯OSAHS组AHI、MAP、ENA-78和MIF含量明显高于正常妊娠组(t=8.92,9.27,10.24,10.23,P均＜0.01)；同时重度OSAHS患者的ENA-78和MIF含量明显高于中度OSAHS组,中度组明显高于轻度组,差异有统计学意义(P均＜0.01).其中OSAHS组患者AHI值与MAP、MIF、ENA-78呈正相关(r=0.75,0.71,0.68,P均＜0.01)；OSAHS组患者ENA-78值与MAP、MIF呈正相关(r =0.65,0.68,P均＜0.01).结论 妊娠合并OSAHS患者病情与ENA-78、MIF水平密切相关；妊娠合并OSAHS部分参与了妊娠期高血压疾病(HDCP)的病理过程.
目的 探討妊娠閤併阻塞性睡眠呼吸暫停低通氣綜閤徵( OSAHS)與血清中性粒細胞激活肽-78(ENA-78)和巨噬細胞移動抑製因子(MIF)的相關性及其意義.方法 選擇妊娠閤併OSAHS患者102例和正常妊娠36例行標準多導睡眠呼吸鑑測繫統鑑測記錄呼吸暫停低通氣指數(AHI)；併根據AHI分為輕度OSAHS組36例,中度OSAHS組34例和重度OSAHS組32例.採用酶聯免疫(ELISA)法檢測血清ENA-78和MIF含量.結果 OSAHS閤併高血壓組AHI、MAP、ENA-78和MIF含量明顯高于單純OSAHS組(t=13.46,11.65,12.47,13.52,P均＜0.01)和正常妊娠組(t=16.72,15.31,16.35,17.43,P均＜0.01),單純OSAHS組AHI、MAP、ENA-78和MIF含量明顯高于正常妊娠組(t=8.92,9.27,10.24,10.23,P均＜0.01)；同時重度OSAHS患者的ENA-78和MIF含量明顯高于中度OSAHS組,中度組明顯高于輕度組,差異有統計學意義(P均＜0.01).其中OSAHS組患者AHI值與MAP、MIF、ENA-78呈正相關(r=0.75,0.71,0.68,P均＜0.01)；OSAHS組患者ENA-78值與MAP、MIF呈正相關(r =0.65,0.68,P均＜0.01).結論 妊娠閤併OSAHS患者病情與ENA-78、MIF水平密切相關；妊娠閤併OSAHS部分參與瞭妊娠期高血壓疾病(HDCP)的病理過程.
목적 탐토임신합병조새성수면호흡잠정저통기종합정( OSAHS)여혈청중성립세포격활태-78(ENA-78)화거서세포이동억제인자(MIF)적상관성급기의의.방법 선택임신합병OSAHS환자102례화정상임신36례행표준다도수면호흡감측계통감측기록호흡잠정저통기지수(AHI)；병근거AHI분위경도OSAHS조36례,중도OSAHS조34례화중도OSAHS조32례.채용매련면역(ELISA)법검측혈청ENA-78화MIF함량.결과 OSAHS합병고혈압조AHI、MAP、ENA-78화MIF함량명현고우단순OSAHS조(t=13.46,11.65,12.47,13.52,P균＜0.01)화정상임신조(t=16.72,15.31,16.35,17.43,P균＜0.01),단순OSAHS조AHI、MAP、ENA-78화MIF함량명현고우정상임신조(t=8.92,9.27,10.24,10.23,P균＜0.01)；동시중도OSAHS환자적ENA-78화MIF함량명현고우중도OSAHS조,중도조명현고우경도조,차이유통계학의의(P균＜0.01).기중OSAHS조환자AHI치여MAP、MIF、ENA-78정정상관(r=0.75,0.71,0.68,P균＜0.01)；OSAHS조환자ENA-78치여MAP、MIF정정상관(r =0.65,0.68,P균＜0.01).결론 임신합병OSAHS환자병정여ENA-78、MIF수평밀절상관；임신합병OSAHS부분삼여료임신기고혈압질병(HDCP)적병리과정.
Objective To investigate the correlation of serum epithelial neutrophil-activing peptide-78( ENA-78),macrophage migration inhibitory factor (MIF) with patients with pregnancy combined with obstructive sleep apnea hypopnea syndrome(OSAHS) and its significance.Methods One hundred and two pregnancy women combined with OSAHS and 36 healthy pregnancy women were randomly selected,and all night polysomnography ( PSG),apnea hypopnea index ( AHI ) were recorded.According to apnea hypopnea index (AHI),they were divided into three groups:36 patients were in mild OSAHS group,34 patients were in moderate OSAHS group and 32 patients were in severe OSAHS group.Serum ENA-78 and MIF levels were detected by enzyme-linked immunosorbent assay (ELISA),and simultaneous determination of mean arterial pressure (MAP).Results The leves of AHI,MAP,ENA-78 and MIF in OSAHS patients complicated with hypertension were significantly higher than those in patients with OSAHS only ( t =13.46,11.65,12.47,13.52,P all ＜0.01 ) and the controls ( t =16.72,15.31,16.35,17.43,P all ＜0.0l ).The levels of AHI、MAP、ENA-78 and MIF were higher in OSAHS group than those in healthy controls (t =8.92,9.27,10.24,10.23,Pall ＜0.01 ).Patients in severe OSAHS group had higher levels of ENA-78 and MIF than moderate OSAHS group,and moderate OSAHS group had higher levels of visfatin and MIF than mild OSAHS group( P ＜ 0.01 ).AHI was positively correlated with MAP,MIF,ENA-78 (r =0.75,0.71,0.68,Pall ＜0.01 ).ENA-78 was positively correlated with MAP and MIF (r =0.65,0.68,P all ＜ 0.01 ).Conclusions The condition of patients with pregnancy combined with OSAHS is closely related with the levels of ENA-78 and MIF.Pregnancy combined with OSAHS may take part in the pathological process of HDCP.
