中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
5期
28-29,31
,共3页
刘慧%李玉东%杨守忠%毛绍芬
劉慧%李玉東%楊守忠%毛紹芬
류혜%리옥동%양수충%모소분
慢性充血性心力衰竭%琥珀酸美托洛尔缓释片%贝那普利%心功能
慢性充血性心力衰竭%琥珀痠美託洛爾緩釋片%貝那普利%心功能
만성충혈성심력쇠갈%호박산미탁락이완석편%패나보리%심공능
Chronic congestive heart failure%Metoprolol succinate sustdined-release tablets%Benazepril%Cardiac function
目的 观察琥珀酸美托洛尔缓释片联合贝那普利治疗慢性充血性心力衰竭(CHF)的疗效.方法 根据NYHA心功能分级,将2006年8月至2007年8月在我院门诊就诊的心功能2~级慢性充血性心力衰竭患者121例,随机分为对照组60例与治疗组6I例.对照组给予常规抗心力衰竭治疗;治疗组在常规治疗应用贝那普利的基础上,应用琥珀酸美托洛尔缓释片治疗12个月,由11.88 mg,1次/d,逐渐增加至95 mg,1坎/d.结果 治疗组临床症状改善,总有效率为85.25%,明显高于对照组的70.00%(P<0.05);两组治疗后心脏射血分数及左室舒张末期容积(LVDD)较治疗前明显改善(P<0.01),且治疗组优于对照组(P<0.05);患者再发心力衰竭及心血管原因的死亡均减少.结论 琥珀酸美托洛尔缓释片联合贝那普利在常规治疗心力衰竭基础上能显著改善惠者临床症状及心功能,比单用贝那普利对治疗更有效,改善预后,可用于慢性CHF的常规治疗.
目的 觀察琥珀痠美託洛爾緩釋片聯閤貝那普利治療慢性充血性心力衰竭(CHF)的療效.方法 根據NYHA心功能分級,將2006年8月至2007年8月在我院門診就診的心功能2~級慢性充血性心力衰竭患者121例,隨機分為對照組60例與治療組6I例.對照組給予常規抗心力衰竭治療;治療組在常規治療應用貝那普利的基礎上,應用琥珀痠美託洛爾緩釋片治療12箇月,由11.88 mg,1次/d,逐漸增加至95 mg,1坎/d.結果 治療組臨床癥狀改善,總有效率為85.25%,明顯高于對照組的70.00%(P<0.05);兩組治療後心髒射血分數及左室舒張末期容積(LVDD)較治療前明顯改善(P<0.01),且治療組優于對照組(P<0.05);患者再髮心力衰竭及心血管原因的死亡均減少.結論 琥珀痠美託洛爾緩釋片聯閤貝那普利在常規治療心力衰竭基礎上能顯著改善惠者臨床癥狀及心功能,比單用貝那普利對治療更有效,改善預後,可用于慢性CHF的常規治療.
목적 관찰호박산미탁락이완석편연합패나보리치료만성충혈성심력쇠갈(CHF)적료효.방법 근거NYHA심공능분급,장2006년8월지2007년8월재아원문진취진적심공능2~급만성충혈성심력쇠갈환자121례,수궤분위대조조60례여치료조6I례.대조조급여상규항심력쇠갈치료;치료조재상규치료응용패나보리적기출상,응용호박산미탁락이완석편치료12개월,유11.88 mg,1차/d,축점증가지95 mg,1감/d.결과 치료조림상증상개선,총유효솔위85.25%,명현고우대조조적70.00%(P<0.05);량조치료후심장사혈분수급좌실서장말기용적(LVDD)교치료전명현개선(P<0.01),차치료조우우대조조(P<0.05);환자재발심력쇠갈급심혈관원인적사망균감소.결론 호박산미탁락이완석편연합패나보리재상규치료심력쇠갈기출상능현저개선혜자림상증상급심공능,비단용패나보리대치료경유효,개선예후,가용우만성CHF적상규치료.
Objective To observe the effect of metoprolol succinate sustained release tablets jointed benazepril in the treatment of chronic congestive heart failure.Methods According to NYHA classitication of cardiac function,A total of 121 patients with NYHA functional class Ⅲ-Ⅳ chronic heart failure from August 2006 to August 2007 in our hospital out-patient were randomly divided into control group of 60 cases and 61 cases of treatment group.Control group was treated with conventional therapy for heart failure,while the treatment group was treated with metoprolol succinate sustdined-release tablet at an initial dose of 11.88 mg once a day but gradually increased to 95 mg once a day,in addition to the conventional therapy of benazepril.Results The total responsive rate in the treatment group(85.25%)was significantly higher than in control group(70.00%)(P<0.05).The ejection fraction in both groups had siguificant improvement as compared with before treatment(P<0.01),with the treatment group showing a better improvement than in control group(P<0.05).Patients with recurrent heart failure and cardiovascular causes of death were reduced.Conclusions Administration of metoprolol succinate sustdined-release tablet plus the conventional therapy can significantly improve the clinical symptoms and cardiac function in patients with chronic congestive heart failure,which is more effective than the single benazepril on the treatment.And it Can improve the prognosis and be used for the routine treatment of chronic CHF.