中华乳腺病杂志（电子版）
中華乳腺病雜誌（電子版）
중화유선병잡지（전자판）
CHINESE JOURNAL OF BREAST DISEASE(ELECTRONIC VERSION)
2009年
4期
398-405
,共8页
李越%赵颖%张斌%葛洁%宁连胜%曹旭晨%于治灏%王欣
李越%趙穎%張斌%葛潔%寧連勝%曹旭晨%于治灝%王訢
리월%조영%장빈%갈길%저련성%조욱신%우치호%왕흔
超声光散射断层成像系统%乳腺肿瘤%彩色多普勒超声%钼靶X线检查
超聲光散射斷層成像繫統%乳腺腫瘤%綵色多普勒超聲%鉬靶X線檢查
초성광산사단층성상계통%유선종류%채색다보륵초성%목파X선검사
Diffused optical tomography with ultrasound%Breast tumor%Ultrasonography%Mammography
目的 探讨运用超声光散射乳腺成像(OPTIMUS)系统对乳腺肿块的诊断价值.方法 回顾经病理检查证实的136例乳腺肿瘤的OPTIMUS系统表现,与病理检查结果对比分析,同时用一致性检验评价其与病理、超声、钼靶X线检查的一致性,并绘制受试者工作特征(receiver operating characteristic, ROC)曲线,计算曲线下面积(area under the curve, AUC),判断三种检查手段的准确性,评价OPTIMUS系统的临床应用价值.结果 136例患者术后病理诊断良性病变50例,恶性病变86例.OPTIMUS系统诊断良性病变34例,恶性病变102例,其中16例被过度诊断为恶性.其与超声及钼靶X线检查的一致性检验Kappa值分别为0.536、0.386.OPTIMUS系统、超声、钼靶X线与病理检查的一致性检验Kappa值分别为0.729、0.616、0.649.OPTIMUS系统、超声及钼靶X线检查的AUC分别为0.840(95%CI 0.764～0.916)、0.817(95%CI 0.742～0.893)及0.837(95%CI 0.771～0.902).结论 OPTIMUS系统对诊断乳腺恶性肿瘤的准确性及敏感性较高,可以提高乳腺癌患者的检出率,减低漏诊率.
目的 探討運用超聲光散射乳腺成像(OPTIMUS)繫統對乳腺腫塊的診斷價值.方法 迴顧經病理檢查證實的136例乳腺腫瘤的OPTIMUS繫統錶現,與病理檢查結果對比分析,同時用一緻性檢驗評價其與病理、超聲、鉬靶X線檢查的一緻性,併繪製受試者工作特徵(receiver operating characteristic, ROC)麯線,計算麯線下麵積(area under the curve, AUC),判斷三種檢查手段的準確性,評價OPTIMUS繫統的臨床應用價值.結果 136例患者術後病理診斷良性病變50例,噁性病變86例.OPTIMUS繫統診斷良性病變34例,噁性病變102例,其中16例被過度診斷為噁性.其與超聲及鉬靶X線檢查的一緻性檢驗Kappa值分彆為0.536、0.386.OPTIMUS繫統、超聲、鉬靶X線與病理檢查的一緻性檢驗Kappa值分彆為0.729、0.616、0.649.OPTIMUS繫統、超聲及鉬靶X線檢查的AUC分彆為0.840(95%CI 0.764～0.916)、0.817(95%CI 0.742～0.893)及0.837(95%CI 0.771～0.902).結論 OPTIMUS繫統對診斷乳腺噁性腫瘤的準確性及敏感性較高,可以提高乳腺癌患者的檢齣率,減低漏診率.
목적 탐토운용초성광산사유선성상(OPTIMUS)계통대유선종괴적진단개치.방법 회고경병리검사증실적136례유선종류적OPTIMUS계통표현,여병리검사결과대비분석,동시용일치성검험평개기여병리、초성、목파X선검사적일치성,병회제수시자공작특정(receiver operating characteristic, ROC)곡선,계산곡선하면적(area under the curve, AUC),판단삼충검사수단적준학성,평개OPTIMUS계통적림상응용개치.결과 136례환자술후병리진단량성병변50례,악성병변86례.OPTIMUS계통진단량성병변34례,악성병변102례,기중16례피과도진단위악성.기여초성급목파X선검사적일치성검험Kappa치분별위0.536、0.386.OPTIMUS계통、초성、목파X선여병리검사적일치성검험Kappa치분별위0.729、0.616、0.649.OPTIMUS계통、초성급목파X선검사적AUC분별위0.840(95%CI 0.764～0.916)、0.817(95%CI 0.742～0.893)급0.837(95%CI 0.771～0.902).결론 OPTIMUS계통대진단유선악성종류적준학성급민감성교고,가이제고유선암환자적검출솔,감저루진솔.
Objective To study the value of diffused optical breast imaging with ultrasound (OPTIMUS, OPTIMUS system) in the diagnosis of breast tumors.Methods The images of 136 breast tumors by OPTIMUS system were reviewed and compared with pathological results. Meanwhile ultrasound and X-ray examinations were performed. Consistency checking was used to evaluate the consistency of pathological, ultrasound and X-ray examinations. The receiver operating characteristic (ROC) curve was done to calculate the area under the curve to evaluate the accuracy of OPTIMUS system and the clinical value of OPTIMUS system in the diagnosis of breast cancer.Results In the 136 cases, pathological diagnosis showed 50 cases were benign and 86 cases malignant. OPTIMUS system diagnosis showed 34 cases were benign and 102 cases malignant; among the 102 cases, 16 were over-diagnosed as cancer. Bases on the pathological results, the consistency checking Kappa value was 0.536 and 0.386 for ultrasound and X-ray examinations respectively,and 0.729, 0.616, and 0.649 for OPTIMUS system, ultrasound and X-ray examinations respectively. The area under ROC
for OPTIMUS system, ultrasound and X-ray examinations was 0.840(95%CI 0.758-0.922), 0.817(95%CI 0.739-0.895) and 0.837(95%CI 0.763-0.910) respectively.Conclusion OPTIMUS system is a non-invasive and highly effective diagnostic tool for breast disease and it could be used as assistant diagnostic tool for breast tumors.
