CAJ | 학술논문

目的:研究IL-18基因编码区105位点多态性与冠心病遗传易感性的关系.方法:采用多聚酶链反应限制性片段长度多态性分析法检测162例冠心病患者和134例对照者IL-18基因编码区105位点基因型,分析其与冠心病易感性的关系.结果:IL-18基因编码区105位点多态性中AA、AC、CC 3种基因型在冠心病组和对照组中的频率分别为70.4%、29.0%、0.6%和88.1%、11.9%、0%.AC基因型患者患冠心病风险为AA基因型者的3.041倍(95% CI 1.631～5.669),C等位基因携带者发生冠心病的风险是A等位基因携带者的2.806倍(95% CI 1.556～5.061)(均P＜0.01).结论:IL-18基因编码区105位点多态性与福建地区部分汉族人群冠心病的发生存在相关性,携带AC、CC基因型人群发生冠心病风险较高.
목적:연구IL-18기인편마구105위점다태성여관심병유전역감성적관계.방법:채용다취매련반응한제성편단장도다태성분석법검측162례관심병환자화134례대조자IL-18기인편마구105위점기인형,분석기여관심병역감성적관계.결과:IL-18기인편마구105위점다태성중AA、AC、CC 3충기인형재관심병조화대조조중적빈솔분별위70.4%、29.0%、0.6%화88.1%、11.9%、0%.AC기인형환자환관심병풍험위AA기인형자적3.041배(95% CI 1.631～5.669),C등위기인휴대자발생관심병적풍험시A등위기인휴대자적2.806배(95% CI 1.556～5.061)(균P＜0.01).결론:IL-18기인편마구105위점다태성여복건지구부분한족인군관심병적발생존재상관성,휴대AC、CC기인형인군발생관심병풍험교고.
Objective:To investigate the association of interleukin-18 gene 105 genetic polymorphism in the coding region with susceptibility to coronary heart disease (CHD).Methods:IL-18 gene 105 genotypes in 162 CHD patients and 134 controls were detected using PCR-restriction fragment length polymorphism(RFLP) assay, and the association of genetic polymorphism with susceptibility to CHD was analyzed. Results:The frequencies of A/A, A/C, C/C types of interleukin-18 gene 105 polymorphism in CHD patients and controls were 70.4%, 29.0% and 0.6%vs 88.1%, 11.9% and 0%. Compared with AA genotype, the relative risk for CHD in people with AC genotype was 3.041(95% confidence interval [CI] 1.631-5.669). The relative risk for CHD in people with C allele was 2.806 higher than people with A allele(95%CI 1.556-5.061)(P＜0.01). Conclusions:IL-18 gene 105 genetic polymorphism is associated with CHD in Han nationality of Fujian province, people with AC or CC genotypes take higher risk of suffering from CHD.