CAJ | 학술논문

分子进化中性学说认为生物的进化主要是由中性突变决定的.基因表达式编程(GEP)是一种将基因型和表现型分离的新的进化模型,其突出表现在基因组存在不被表达的中性区.基于朴素基因表达式编程(NGEP)模型研究了NGEP中性区在进化中的作用.主要工作包括:1)进一步完善了基于完全树编码方案的NGEP模型的概念;2)分析了传统GEP和NGEP的基因中性区域特点,指出NGEP存在更自由灵活的中性区域;3)通过控制基因长度和基因数量,调控中性区的大小和数量,研究了NGEP和传统GEP的中性区域在进化中的特殊作用,验证了NGEP的有效性;4)实验表明,在存在相同适度的中性区域条件下,NGEP比传统GEP进化更有效,且NGEP的成功率随中性区域的增加不会发生剧烈变化.
분자진화중성학설인위생물적진화주요시유중성돌변결정적.기인표체식편정(GEP)시일충장기인형화표현형분리적신적진화모형,기돌출표현재기인조존재불피표체적중성구.기우박소기인표체식편정(NGEP)모형연구료NGEP중성구재진화중적작용.주요공작포괄:1)진일보완선료기우완전수편마방안적NGEP모형적개념;2)분석료전통GEP화NGEP적기인중성구역특점,지출NGEP존재경자유령활적중성구역;3)통과공제기인장도화기인수량,조공중성구적대소화수량,연구료NGEP화전통GEP적중성구역재진화중적특수작용,험증료NGEP적유효성;4)실험표명,재존재상동괄도적중성구역조건하,NGEP비전통GEP진화경유효,차NGEP적성공솔수중성구역적증가불회발생극렬변화.
The neutral theory of molecular evolution suggests that the accumulation of neutral mutations in the genome plays a vital role in evolutions. The genetic representation of gene expression programming (GEP), an artificial genotype and phenotype system, permits the existence of non-coding regions in the genome where neutral mutations can be programming (NGEP) and analyze the effect in terms of neutral regions. NGEP uses the complete tree decoding method that causes more neutral regions than GEP. In order to explore the role of the genetic neutrality in NGEP, this paper makes the following contributions: 1)perfect the based on complete tree;2)analyze the characteristic of neutral regions in GEP and NGEP, and point out that NGEP has more free neutrality regions;3)study and compare the specific role of genetic neutrality for both GEP and NGEP by controlling and adjusting the length and the number of genes and these non-coding regions, and tests the efficiency of NGEP;and 4)extensive experiments and comparisons show that NGEP is more efficient than traditional GEP in the case of similar gene redundancy, in particular, the success rate of NGEP does not change drastically with the growth of genetic neutrality.