CAJ | 학술논문

以S-2-N-(N′-苄基-S-脯氨酰)-氨基二苯甲酮-镍(Ⅱ)-甘氨酸(BPB-Ni(Ⅱ)-Gly)复合物为手性助剂,与1,4-二溴丁烷反应制备了标题化合物.探讨了反应时间以及反应物配比对反应产率影响,确定了最佳反应条件:BPB-Ni(Ⅱ)-Gly复合物与1,4-二溴丁烷的物质的量比为1∶0.5,反应时间为10 min.2S,7S-二氨基辛二酸的总产率为63%.同时用核磁共振、高分辨质谱及旋光技术对产物进行了表征.
이S-2-N-(N′-변기-S-포안선)-안기이분갑동-얼(Ⅱ)-감안산(BPB-Ni(Ⅱ)-Gly)복합물위수성조제,여1,4-이추정완반응제비료표제화합물.탐토료반응시간이급반응물배비대반응산솔영향,학정료최가반응조건:BPB-Ni(Ⅱ)-Gly복합물여1,4-이추정완적물질적량비위1∶0.5,반응시간위10 min.2S,7S-이안기신이산적총산솔위63%.동시용핵자공진、고분변질보급선광기술대산물진행료표정.
2S,7S-Diaminosuberic acid was asymmetrically synthesized by reacting Gly-Ni-2[N-(N′-benzylprolyl)amino]benzophenone as the chiral auxiliary with 1,4-dibromobutane.The effect of the molar ratio of Ni(Ⅱ) complexes of glycine Schiff base to 1,4-dibromobutane and the reaction time on the yield of intermediates was investigated.The optimal reaction conditions were determined as follows:a molar ratio of 1∶0.5,and a reaction time of 10 min.The yield of 2S,7S-diaminosuberic acid was 63%.All products were characterized by NMR,MS,and optical rotation technique.