CAJ | 학술논문

目的研究医药级甜菜碱柠檬酸盐适合工业化生产的合成工艺.方法由氯乙酸三甲胺和柠檬酸合成甜菜碱柠檬酸盐,并对合成条件进行了讨论和中试实验放大,对产物进行了表征及含量测定.结果产物结构由IR和元素分析得到证明,产物含量用非水滴定法进行了测定.最佳工艺条件下收率92.03%,纯度99.1%,并在设计的中试装置中进行了放大实验,工艺放大效应不明显.结论合成工艺及放大实验表明,工艺适用于工业规模制备医药级甜菜碱柠檬酸盐.
목적 연구의약급첨채감저몽산염괄합공업화생산적합성공예.방법 유록을산삼갑알화저몽산합성첨채감저몽산염,병대합성조건진행료토론화중시실험방대,대산물진행료표정급함량측정.결과 산물결구유IR화원소분석득도증명,산물함량용비수적정법진행료측정.최가공예조건하수솔92.03%,순도99.1%,병재설계적중시장치중진행료방대실험,공예방대효응불명현.결론 합성공예급방대실험표명,공예괄용우공업규모제비의약급첨채감저몽산염.
Aim To synthesize medicinal betaine citrate and suit manufacture.Methods Betaine citrate was synthesized from chloroactic acid,trimethylamine and citrate.The synthetic conditions and pilot were studied.The produet was analyzed by non-aqueous titration.Results The structure of the product was confirmed by IR spectra and elemental analysis.The content can reach 99.1% with yield of 92.03% under the optimum conditions.Pilot equipments was designed and manufactured.Conclusion The synthetic method of medicinal betaine citrate is feasible,and helpful for industrial production.