国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2011年
1期
30-33,49
,共5页
壳聚糖%羧甲基壳聚糖%制备%取代度
殼聚糖%羧甲基殼聚糖%製備%取代度
각취당%최갑기각취당%제비%취대도
Chitosan%Carboxymethyl chitosan%Preparation%Degree of substitution
目的 壳聚糖具有优良的生物相容性和生物可降解性,但其亲水性较差难以满足组织工程的需要.为满足组织工程支架材料的需求,对壳聚糖进行羧甲基化改性,以期改善其溶解性能.方法 通过3种不同的方法来摸索3种不同取代位置的羧甲基壳聚糖(CMC)的制备工艺,分别考察了原料比、反应时间、反应温度等影响因素对产物取代度(DS)的影响.结果 摸索得到3种羧甲基壳聚糖的最佳制备工艺条件,以这种工艺条件制备产物水溶性良好.结论 通过羧甲基化反应可以大大改善壳聚糖的水溶解性能,为以后更深一步的研究提供了科研基础和实验依据.
目的 殼聚糖具有優良的生物相容性和生物可降解性,但其親水性較差難以滿足組織工程的需要.為滿足組織工程支架材料的需求,對殼聚糖進行羧甲基化改性,以期改善其溶解性能.方法 通過3種不同的方法來摸索3種不同取代位置的羧甲基殼聚糖(CMC)的製備工藝,分彆攷察瞭原料比、反應時間、反應溫度等影響因素對產物取代度(DS)的影響.結果 摸索得到3種羧甲基殼聚糖的最佳製備工藝條件,以這種工藝條件製備產物水溶性良好.結論 通過羧甲基化反應可以大大改善殼聚糖的水溶解性能,為以後更深一步的研究提供瞭科研基礎和實驗依據.
목적 각취당구유우량적생물상용성화생물가강해성,단기친수성교차난이만족조직공정적수요.위만족조직공정지가재료적수구,대각취당진행최갑기화개성,이기개선기용해성능.방법 통과3충불동적방법래모색3충불동취대위치적최갑기각취당(CMC)적제비공예,분별고찰료원료비、반응시간、반응온도등영향인소대산물취대도(DS)적영향.결과 모색득도3충최갑기각취당적최가제비공예조건,이저충공예조건제비산물수용성량호.결론 통과최갑기화반응가이대대개선각취당적수용해성능,위이후경심일보적연구제공료과연기출화실험의거.
Objective Although chitosan has excellent biocompatibility and biodegradability, it is only soluble in acid solution that is not feasible for application in tissue engineering. The current study is aimed to prepare the carboxymethyl chitosan (CMC) for the purpose of improving the solubility of chitosan to meet the requirement of development of tissue engineering scaffolds. Methods The preparation methods and process conditions, such as the proportion of reactant, reaction temperature, reaction time and so on for three types of carboxymethyl chitosan were studied. Results The results indicated that optimal process conditions of three types of water soluble chitosan were obtained. Conclusion Water solubility of chitosan is greatly improved through carboxymethyl modification, which provides possibilities and foundation for further research.
