CAJ | 학술논문

铜绿假单胞菌(PA)对多种抗菌药物都有不同程度的耐药,其耐药机制包括酶的产生、生物被膜的形成、外排泵的高表达和外膜孔蛋白表达的降低或缺失,其中多药外排泵能排出多种结构和功能不相关的抗菌药物,包括β-内酰胺类、氟喹诺酮类、大环内酯类、氨基糖苷类、四环素、氯霉素等,目前被认为是导致PA固有和获得性多重耐药的重要原因.
동록가단포균(PA)대다충항균약물도유불동정도적내약,기내약궤제포괄매적산생、생물피막적형성、외배빙적고표체화외막공단백표체적강저혹결실,기중다약외배빙능배출다충결구화공능불상관적항균약물,포괄β-내선알류、불규낙동류、대배내지류、안기당감류、사배소、록매소등,목전피인위시도치PA고유화획득성다중내약적중요원인.
Pseudomonas aeruginosa is resistant to many amibactedcal agents to different extent,its mechanisms involve generation enzymes,formation of biofilm,over expression of efllux pump,as well as low expression or eveg loss of porin,and multidrug efflux pump can efflux many construction and fuction unrelated antibacterical agents,including β-lactam,fluoroquinoiones,macrolides,aminoglycosides,tetracycline,chloramphenicol and so on.It is presumed as the nain reason for the inherent and acquired multidrug resistance of Pseudomonas aeruginosa at present.