CAJ | 학술논문

肠道内存在大最的共生菌,共生菌与肠上皮组织之间通过一定的相互作用机制而保持稳定的耐受状态,当肠道菌群紊乱时会打破这一平衡,通过Toll样受体(TLR)或核苷酸结合寡聚化结构域(NOD)识别激活NF-кB,促进炎症基因的转录,大量炎症介质释放,引起肠黏膜损伤.近年从分子基因水平上发现益生菌能通过抑制NF-кB而减轻炎症反应,起抗炎作用的可以是活菌,也可以是灭活菌或DNA.
장도내존재대최적공생균,공생균여장상피조직지간통과일정적상호작용궤제이보지은정적내수상태,당장도균군문란시회타파저일평형,통과Toll양수체(TLR)혹핵감산결합과취화결구역(NOD)식별격활NF-кB,촉진염증기인적전록,대량염증개질석방,인기장점막손상.근년종분자기인수평상발현익생균능통과억제NF-кB이감경염증반응,기항염작용적가이시활균,야가이시멸활균혹DNA.
The intestine contains numerous commensal bacteria. The commensal bacterial and intestinal epithelium interact with each other through a certain mechanism, restdting in a situation of tolerance, which can be broken up by the disturbance of the intestinal flora. The bacteria can be recognized by TLR(Toll-like receptor) or NOD( nucleotide-binding a large number of inflammatory mediators are released to cause the damage of the intestinal mucosa. In recent years, it The inactivated probiotic or its DNA may have the same function with the live one.