中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2011年
10期
724-728
,共5页
梁云%陈晓端%吕炳建%周彩云%张晓飞%石海燕
樑雲%陳曉耑%呂炳建%週綵雲%張曉飛%石海燕
량운%진효단%려병건%주채운%장효비%석해연
输卵管肿瘤%癌%原位%盆腔肿瘤%囊腺癌%浆液
輸卵管腫瘤%癌%原位%盆腔腫瘤%囊腺癌%漿液
수란관종류%암%원위%분강종류%낭선암%장액
Fallopian tube neoplasms%Carcinoma in situ%Pelvic neoplasms%Cystadenocarcinoma%serous
目的 初步探讨发生于伞端的输卵管上皮内癌(TIC)与高级别盆腔浆液性癌发生的关系.方法 选取2009年1月至2010年6月间因原发性高级别盆腔浆液性癌行手术治疗的患者中输卵管伞端结构清晰的全部患者34例作为研究组,包括卵巢浆液性癌26例(卵巢表面受累12例,实质受累14例)、输卵管浆液性癌7例及腹膜浆液性癌l例.选择同期全部原发性非高级别盆腔浆液性癌42例作为对照组,包括卵巢子宫内膜样癌13例、卵巢透明细胞癌11例、卵巢黏液样腺癌11例、低级别卵巢浆液性癌6例、低级别输卵管浆液性癌1例.分析两组患者中TIC存在情况,根据是否存在TIC将高级别卵巢浆液性癌患者分为TIC阳性(+)和TIC阴性(-)两类,并比较两者的临床病理特点.结果 研究组34例高级别盆腔浆液性癌患者中,15例(44%)存在TIC,病变均位于输卵管伞端,对照组中未发现存在TIC,两组TIC发生率比较,差异有统计学意义(x2=23.086,P=0.000).26例高级别卵巢浆液性癌患者中,11例(42%)存在TIC,其中8例单侧卵巢浆液性癌患者存在同侧TIC、2例双侧卵巢浆液性癌患者存在单侧TIC、1例双侧卵巢浆液性癌患者存在双侧TIC;7例高级别输卵管浆液性癌患者中,4例(4/7)存在TIC;1例高级别腹膜浆液性癌未发现TIC.26例高级别卵巢浆液性癌患者中,11例TIC(+)和15例TIC(-)患者中卵巢实质受累分别为5例(5/11)和9例(9/15),卵巢表面受累分别为6例(6/11)和6例(6/15),分别比较,差异均无统计学意义(P>0.05);其卵巢肿瘤平均长径分别为6.9和6.5cm,两者比较,差异也无统计学意义(t=0.409,P=0.690).结论 伞端TIC可能是高级别盆腔浆液性癌特有的,与高级别盆腔浆液性癌的发生可能有一定的关系.
目的 初步探討髮生于傘耑的輸卵管上皮內癌(TIC)與高級彆盆腔漿液性癌髮生的關繫.方法 選取2009年1月至2010年6月間因原髮性高級彆盆腔漿液性癌行手術治療的患者中輸卵管傘耑結構清晰的全部患者34例作為研究組,包括卵巢漿液性癌26例(卵巢錶麵受纍12例,實質受纍14例)、輸卵管漿液性癌7例及腹膜漿液性癌l例.選擇同期全部原髮性非高級彆盆腔漿液性癌42例作為對照組,包括卵巢子宮內膜樣癌13例、卵巢透明細胞癌11例、卵巢黏液樣腺癌11例、低級彆卵巢漿液性癌6例、低級彆輸卵管漿液性癌1例.分析兩組患者中TIC存在情況,根據是否存在TIC將高級彆卵巢漿液性癌患者分為TIC暘性(+)和TIC陰性(-)兩類,併比較兩者的臨床病理特點.結果 研究組34例高級彆盆腔漿液性癌患者中,15例(44%)存在TIC,病變均位于輸卵管傘耑,對照組中未髮現存在TIC,兩組TIC髮生率比較,差異有統計學意義(x2=23.086,P=0.000).26例高級彆卵巢漿液性癌患者中,11例(42%)存在TIC,其中8例單側卵巢漿液性癌患者存在同側TIC、2例雙側卵巢漿液性癌患者存在單側TIC、1例雙側卵巢漿液性癌患者存在雙側TIC;7例高級彆輸卵管漿液性癌患者中,4例(4/7)存在TIC;1例高級彆腹膜漿液性癌未髮現TIC.26例高級彆卵巢漿液性癌患者中,11例TIC(+)和15例TIC(-)患者中卵巢實質受纍分彆為5例(5/11)和9例(9/15),卵巢錶麵受纍分彆為6例(6/11)和6例(6/15),分彆比較,差異均無統計學意義(P>0.05);其卵巢腫瘤平均長徑分彆為6.9和6.5cm,兩者比較,差異也無統計學意義(t=0.409,P=0.690).結論 傘耑TIC可能是高級彆盆腔漿液性癌特有的,與高級彆盆腔漿液性癌的髮生可能有一定的關繫.
목적 초보탐토발생우산단적수란관상피내암(TIC)여고급별분강장액성암발생적관계.방법 선취2009년1월지2010년6월간인원발성고급별분강장액성암행수술치료적환자중수란관산단결구청석적전부환자34례작위연구조,포괄란소장액성암26례(란소표면수루12례,실질수루14례)、수란관장액성암7례급복막장액성암l례.선택동기전부원발성비고급별분강장액성암42례작위대조조,포괄란소자궁내막양암13례、란소투명세포암11례、란소점액양선암11례、저급별란소장액성암6례、저급별수란관장액성암1례.분석량조환자중TIC존재정황,근거시부존재TIC장고급별란소장액성암환자분위TIC양성(+)화TIC음성(-)량류,병비교량자적림상병리특점.결과 연구조34례고급별분강장액성암환자중,15례(44%)존재TIC,병변균위우수란관산단,대조조중미발현존재TIC,량조TIC발생솔비교,차이유통계학의의(x2=23.086,P=0.000).26례고급별란소장액성암환자중,11례(42%)존재TIC,기중8례단측란소장액성암환자존재동측TIC、2례쌍측란소장액성암환자존재단측TIC、1례쌍측란소장액성암환자존재쌍측TIC;7례고급별수란관장액성암환자중,4례(4/7)존재TIC;1례고급별복막장액성암미발현TIC.26례고급별란소장액성암환자중,11례TIC(+)화15례TIC(-)환자중란소실질수루분별위5례(5/11)화9례(9/15),란소표면수루분별위6례(6/11)화6례(6/15),분별비교,차이균무통계학의의(P>0.05);기란소종류평균장경분별위6.9화6.5cm,량자비교,차이야무통계학의의(t=0.409,P=0.690).결론 산단TIC가능시고급별분강장액성암특유적,여고급별분강장액성암적발생가능유일정적관계.
Objective To explore the relationship between tubal intraepithelial carcinoma (TIC) of the fimbria and pelvic high-grade serous carcinoma.Methods All 34 cases of pelvic high-grade serous carcinoma with clear fimbria were evaluated from January 2009 to June 2010,including ovarian carcinoma (n=26),tubal carcinoma (n=7) and peritoneal carcinoma (n=1).Among of these ovarian carcinomas,12 cases were surface deposits and the other 14 cases within ovarian parenchyma.All 42 cases of non highgrade serous carcinoma in this period including 13 endometrioid ovary carcinomas,11 clear cell ovary carcinomas,11 mucinous ovary carcinomas,6 low-grade serous ovary carcinomas,1 low-grade serous tubal carcinoma,were also collected as a reference.The presence of tubal intraepithelial carcinomas was assessed.Based on the presence of TIC,high-grade serous ovary carcinomas were divided into TIC positive (+) and TIC negative (-) groups,and the clinical and pathological features of them were also evaluated.Results Fifteen cases (44%) were identified TIC in 34 high-grade pelvic serous carcinomas,and all of them were in the fimbria only,while none of TIC was found in control cases.There were significant difference between the two groups (x2=23.086,P=0.000).Eleven cases(42%) were identified TIC in all 26 high-grade ovarian serous carcinomas,in which 8 cases with unilateral ovary carcinomas were associated with ipsilateral TIC,2 cases with bilateral ovary carcinomas associated with unilateral TIC and one case with bilateral ovary carcinoma was associated with bilateral TIC.Four TIC (4/7) were identified in 7 cases with high-grade tubal serous carcinomas,and there was no presence of TIC in the 1 high-grade serous peritoneal carcinoma.Of all 26 high-grade ovarian serous carcinomas,6/11 cases were surface deposits,and 5/11 were parenchyma tumors in TIC (+) group while 6/15 cases were surface deposits and 9/15 were parenchyma tumors in TIC (-) group,in which there were correlated in distribution of TIC between the two groups( P>0.05 ).The average diameter of ovarian cancer were 6.9 and 6.5 cm between the two groups with no significant differences ( t=0.409,P=0.690).Conclusion TIC is specific to high-grade serous carcinomas and maybe have something to do with the pathogenesis of pelvic serous carcinomas.