中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年
12期
1015-1019
,共5页
卓超%肖书念%邱桂霞%钟南山
卓超%肖書唸%邱桂霞%鐘南山
탁초%초서념%구계하%종남산
哌拉西林-舒巴坦%抗菌药%非发酵菌%微生物敏感性试验
哌拉西林-舒巴坦%抗菌藥%非髮酵菌%微生物敏感性試驗
고랍서림-서파탄%항균약%비발효균%미생물민감성시험
Piperacillin-sulbactam%Anti-bacterial agents%Non-fermentative bacilli%Microbial sensitivity tests
目的 评价哌拉西林-舒巴坦等7种药物对非发酵菌的体外抗菌活性.方法 采用微量肉汤稀释法测定哌拉西林-舒巴坦对细菌的体外抗菌作用.结果 广州地区6家医院共收集菌株770株,其中铜绿假单胞菌216株,鲍曼不动杆菌242株,嗜麦芽窄食单胞菌100株,洋葱伯克霍尔德菌119株,黄杆菌属57株,产碱杆菌属36株.对所有铜绿假单胞菌,哌拉西林-舒巴坦的敏感性最高(71.9%),而亚胺培南、头孢吡肟、头孢他啶、头孢哌酮-舒巴坦敏感性均低于50%.对亚胺培南不敏感的铜绿假单胞菌,哌拉西林-舒巴坦敏感性仍可达55.8%.对碳青霉烯敏感的鲍曼不动杆菌,哌拉西林-舒巴坦和头孢哌酮-舒巴坦敏感性最高,分别为71.0%和73.0%.对嗜麦芽窄食单胞菌,26%和20%的菌株对哌拉西林-舒巴坦和哌拉西林-他唑巴坦的最低抑菌浓度(MIC)≤16 mg/L.对洋葱伯克霍尔德菌,69%的菌株对哌拉西林-舒巴坦的MIC≤16 mg/L.对黄杆菌属和产碱杆菌属,哌拉西林-舒巴坦、头孢哌酮-舒巴坦和哌拉西林他唑巴坦3种加酶复合制剂敏感性最高,分别为70.2%、63.2%、57.9%和94.4%、94.4%、91. 7%.结论 哌拉西林-舒巴坦对多种非发酵菌尤其是碳青霉烯不敏感的铜绿假单胞菌具有良好的体外抗菌活性.
目的 評價哌拉西林-舒巴坦等7種藥物對非髮酵菌的體外抗菌活性.方法 採用微量肉湯稀釋法測定哌拉西林-舒巴坦對細菌的體外抗菌作用.結果 廣州地區6傢醫院共收集菌株770株,其中銅綠假單胞菌216株,鮑曼不動桿菌242株,嗜麥芽窄食單胞菌100株,洋蔥伯剋霍爾德菌119株,黃桿菌屬57株,產堿桿菌屬36株.對所有銅綠假單胞菌,哌拉西林-舒巴坦的敏感性最高(71.9%),而亞胺培南、頭孢吡肟、頭孢他啶、頭孢哌酮-舒巴坦敏感性均低于50%.對亞胺培南不敏感的銅綠假單胞菌,哌拉西林-舒巴坦敏感性仍可達55.8%.對碳青黴烯敏感的鮑曼不動桿菌,哌拉西林-舒巴坦和頭孢哌酮-舒巴坦敏感性最高,分彆為71.0%和73.0%.對嗜麥芽窄食單胞菌,26%和20%的菌株對哌拉西林-舒巴坦和哌拉西林-他唑巴坦的最低抑菌濃度(MIC)≤16 mg/L.對洋蔥伯剋霍爾德菌,69%的菌株對哌拉西林-舒巴坦的MIC≤16 mg/L.對黃桿菌屬和產堿桿菌屬,哌拉西林-舒巴坦、頭孢哌酮-舒巴坦和哌拉西林他唑巴坦3種加酶複閤製劑敏感性最高,分彆為70.2%、63.2%、57.9%和94.4%、94.4%、91. 7%.結論 哌拉西林-舒巴坦對多種非髮酵菌尤其是碳青黴烯不敏感的銅綠假單胞菌具有良好的體外抗菌活性.
목적 평개고랍서림-서파탄등7충약물대비발효균적체외항균활성.방법 채용미량육탕희석법측정고랍서림-서파탄대세균적체외항균작용.결과 엄주지구6가의원공수집균주770주,기중동록가단포균216주,포만불동간균242주,기맥아착식단포균100주,양총백극곽이덕균119주,황간균속57주,산감간균속36주.대소유동록가단포균,고랍서림-서파탄적민감성최고(71.9%),이아알배남、두포필우、두포타정、두포고동-서파탄민감성균저우50%.대아알배남불민감적동록가단포균,고랍서림-서파탄민감성잉가체55.8%.대탄청매희민감적포만불동간균,고랍서림-서파탄화두포고동-서파탄민감성최고,분별위71.0%화73.0%.대기맥아착식단포균,26%화20%적균주대고랍서림-서파탄화고랍서림-타서파탄적최저억균농도(MIC)≤16 mg/L.대양총백극곽이덕균,69%적균주대고랍서림-서파탄적MIC≤16 mg/L.대황간균속화산감간균속,고랍서림-서파탄、두포고동-서파탄화고랍서림타서파탄3충가매복합제제민감성최고,분별위70.2%、63.2%、57.9%화94.4%、94.4%、91. 7%.결론 고랍서림-서파탄대다충비발효균우기시탄청매희불민감적동록가단포균구유량호적체외항균활성.
Objective To evaluate the in vitro antimicrobial activity of piperacillin-sulbactam against clinical isolates of non-fermentative bacilli isolated from common infections. Methods Microdilution was employed to study the antimicrobial resistance. Results A total of 770 strains were collected from 6 hospitals in Guangzhou, including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia , Burkholderia cepacia , Flavobacterium , and Alcaligenes. Compared with other β-lactams,piperacillin-sulbactam displayed the highest activity against all the isolates of P. aeruginosa, especially for imipenem non-sensitive isolates, with the susceptibility of 71.9% and 55.8%, respectively. Piperacillinsulbactam and cefoperazone-sulbactam kept good activity against imipenem sensitive isolates of A. baumannii,with the susceptibility of 71.0% and 73. 0%, respectively. For the strains of Burkholderia cepacia, 69% strains exhibited minimal inhibitory concentration (MIC) of ≤ 16 mg/L for piperacillin-sulbactam. For the strains of Flavobacterium, and Alcaligenes, piperacillin-sulbactam also had excellent activity, with the susceptibility of 70. 2% and 94. 4%, respectively. Conclusion Piperacillin-sulbactam exhibits good activity again non-fermentative bacilli, especial for imipenem non-sensitive isolates of P. aeruginosa.
