中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2012年
1期
40-43
,共4页
刘斌%黄盛%王畅%王祎波%焦亚彬%戴露使%林瑞娇%王瑜
劉斌%黃盛%王暢%王祎波%焦亞彬%戴露使%林瑞嬌%王瑜
류빈%황성%왕창%왕의파%초아빈%대로사%림서교%왕유
糖尿病,2型%胃旁路术%血红蛋白A,糖基化%血糖
糖尿病,2型%胃徬路術%血紅蛋白A,糖基化%血糖
당뇨병,2형%위방로술%혈홍단백A,당기화%혈당
Diabetes mellitus,type 2%Gastric bypass%Hemoglobin A,glycosylated%Blood glucose
目的 分析影响Goto-Kakizaki(GK)大鼠Roux-en-Y胃旁路术后降糖效果的相关因素.方法 回顾性分析GK大鼠术前(0周)、术后1、3、6、12、24周摄食量、体质量、空腹血糖及术前(0周)、术后4、12、24周各时间点糖化血红蛋白(HbAlc)水平,探讨影响胃旁路术后降糖效果的相关性因素.依据术前HbAlc水平将GK大鼠分为A组,HbAlc 6.5％～7.9％；B组,HbAlc 8.0％～9.9％；C组,HbAlc＞ 10％,以评估术前HbAlc水平与胃旁路术后降糖效果之间的相关性.结果 与术前相比,大鼠术后1～24周空腹血糖、HbAlc均明显下降(P＜0.01),术后24周时空腹血糖由(12.1 ±3.0)mmol/L下降到(7.6±1.3)mmol/L,HbAlc由(9.2％±1.8％)下降到(6.3％±0.8％).治愈组与好转组相比,术前空腹血糖分别为(11.1±2.2)、(15.8±2.3)mmol/L,HbAlc分别为(8.6％±1.4％)、(11.5％±1.4％),两组之间相比差异有统计学意义(均P＜0.01),而两组大鼠术前摄食量及体质量之间相比差异无统计学意义(P＞0.05).非条件Logistic逐步回归分析显示术前HbAlc对该手术的治愈率与好转率有预测价值(P＜0.01).A组与C组、B组与C组降糖效果相比差异有统计学意义(P＜0.01),而A组与B组相比差异无统计学意义(P＞0.05).结论 GK大鼠术前HbAlc水平与胃旁路术后降糖效果具有相关性,且术前HbAlc＜ 10％时降糖效果较好.
目的 分析影響Goto-Kakizaki(GK)大鼠Roux-en-Y胃徬路術後降糖效果的相關因素.方法 迴顧性分析GK大鼠術前(0週)、術後1、3、6、12、24週攝食量、體質量、空腹血糖及術前(0週)、術後4、12、24週各時間點糖化血紅蛋白(HbAlc)水平,探討影響胃徬路術後降糖效果的相關性因素.依據術前HbAlc水平將GK大鼠分為A組,HbAlc 6.5％～7.9％；B組,HbAlc 8.0％～9.9％；C組,HbAlc＞ 10％,以評估術前HbAlc水平與胃徬路術後降糖效果之間的相關性.結果 與術前相比,大鼠術後1～24週空腹血糖、HbAlc均明顯下降(P＜0.01),術後24週時空腹血糖由(12.1 ±3.0)mmol/L下降到(7.6±1.3)mmol/L,HbAlc由(9.2％±1.8％)下降到(6.3％±0.8％).治愈組與好轉組相比,術前空腹血糖分彆為(11.1±2.2)、(15.8±2.3)mmol/L,HbAlc分彆為(8.6％±1.4％)、(11.5％±1.4％),兩組之間相比差異有統計學意義(均P＜0.01),而兩組大鼠術前攝食量及體質量之間相比差異無統計學意義(P＞0.05).非條件Logistic逐步迴歸分析顯示術前HbAlc對該手術的治愈率與好轉率有預測價值(P＜0.01).A組與C組、B組與C組降糖效果相比差異有統計學意義(P＜0.01),而A組與B組相比差異無統計學意義(P＞0.05).結論 GK大鼠術前HbAlc水平與胃徬路術後降糖效果具有相關性,且術前HbAlc＜ 10％時降糖效果較好.
목적 분석영향Goto-Kakizaki(GK)대서Roux-en-Y위방로술후강당효과적상관인소.방법 회고성분석GK대서술전(0주)、술후1、3、6、12、24주섭식량、체질량、공복혈당급술전(0주)、술후4、12、24주각시간점당화혈홍단백(HbAlc)수평,탐토영향위방로술후강당효과적상관성인소.의거술전HbAlc수평장GK대서분위A조,HbAlc 6.5％～7.9％；B조,HbAlc 8.0％～9.9％；C조,HbAlc＞ 10％,이평고술전HbAlc수평여위방로술후강당효과지간적상관성.결과 여술전상비,대서술후1～24주공복혈당、HbAlc균명현하강(P＜0.01),술후24주시공복혈당유(12.1 ±3.0)mmol/L하강도(7.6±1.3)mmol/L,HbAlc유(9.2％±1.8％)하강도(6.3％±0.8％).치유조여호전조상비,술전공복혈당분별위(11.1±2.2)、(15.8±2.3)mmol/L,HbAlc분별위(8.6％±1.4％)、(11.5％±1.4％),량조지간상비차이유통계학의의(균P＜0.01),이량조대서술전섭식량급체질량지간상비차이무통계학의의(P＞0.05).비조건Logistic축보회귀분석현시술전HbAlc대해수술적치유솔여호전솔유예측개치(P＜0.01).A조여C조、B조여C조강당효과상비차이유통계학의의(P＜0.01),이A조여B조상비차이무통계학의의(P＞0.05).결론 GK대서술전HbAlc수평여위방로술후강당효과구유상관성,차술전HbAlc＜ 10％시강당효과교호.
Objective To analyze the related factors associated with the effect of Roux-en-Y gastric bypass in Goto-Kakizaki rats.Methods In GK rats undergoing Roux-en-Y gastric bypass,the weight,food intake,and the fasting blood glucose were retrospectively analyzed before surgery and 1,3,6,12,24 weeks after surgery,and the glycosylated haemoglobin concentrations were retrospectively analyzed before surgery and 4,12,24 weeks after surgery.According to preoperative glycosylated haemoglobin concentrations,GK rats were divided into 3 groups(group A,HbAlc 6.5％-7.9％; group B,HbAlc 8.0％-9.9％ ; group C,HbAlc ＞ 10％).Results The fasting blood glucose and the glycosylated haemoglobin concentrations significantly decreased 1 week after surgery(P ＜ 0.01),on 24 weeks after operation,the fasting blood glucose levels decreased from(12.1 ± 3.0)mmol/L to(7.6 ± 1.3)mmol/L,and the glycosylated haemoglobin concentrations declined from(9.2％ ± 1.8％)to(6.3％ ± 0.8％).Preoperative fasting blood glucose was(11.1 ± 2.2)mmol/L and(15.8 ± 2.3)mmol/L respectively,and the preoperative glycosylated haemoglobin concentration was(8.6％ ± 1.4％)and(11.5％ ± 1.4％)respectively(P ＜ 0.01).Non-conditional Logistic regression analysis identified preoperative glycosylated haemoglobin concentrations as an independent predictor for the cure rate(P ＜ 0.01); Differences were significant between group A and group C,and group B and group C on the efficiency of the surgery(P ＜0.01).Conclusions Significant correlation established between glycosylated haemoglobin concentrations and the efficiency of the surgery,especially for those rats with preoperative HbAlc ＜ 10％.
