肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
2期
89-91
,共3页
彭仙娥%江荧荧%李林%黄之敏%胡志坚%史习舜
彭仙娥%江熒熒%李林%黃之敏%鬍誌堅%史習舜
팽선아%강형형%리림%황지민%호지견%사습순
肠肿瘤%乙酰基转移酶类%基凶多态性%疾病遗传易感性%环境暴露
腸腫瘤%乙酰基轉移酶類%基兇多態性%疾病遺傳易感性%環境暴露
장종류%을선기전이매류%기흉다태성%질병유전역감성%배경폭로
Intestinal neoplasms%Acetyhransferases%Genetic susceptibility%Geneticpredisposition to disease%Environmental exposures
目的 探讨N-乙酰基转移酶-2(NAT2)基因多态性及环境暴露与大肠癌易感性的关系.方法 以病例对照研究方法,采用聚合酶链反应.限制性片段长度多态性(PCR-RFLP)基因分型技术,对86对大肠癌患者和非肿瘤患者(对照组)NAT2基因型进行测定.结果 NAT2 慢速基凶型在病例组的频率为19.58%(56例),对照组为10.14%(29例),差异具有统计学意义(χ~2 10.07,P:0.00).携带NAT2慢速基因型的个体患大肠癌的风险(OR)是携带快速基因型个体的2.16倍(95%C:1.31～3.54).结论 NAT2基因多态性与大肠癌的易感性有关,携带慢速基因型的人群患大肠癌的风险增加.
目的 探討N-乙酰基轉移酶-2(NAT2)基因多態性及環境暴露與大腸癌易感性的關繫.方法 以病例對照研究方法,採用聚閤酶鏈反應.限製性片段長度多態性(PCR-RFLP)基因分型技術,對86對大腸癌患者和非腫瘤患者(對照組)NAT2基因型進行測定.結果 NAT2 慢速基兇型在病例組的頻率為19.58%(56例),對照組為10.14%(29例),差異具有統計學意義(χ~2 10.07,P:0.00).攜帶NAT2慢速基因型的箇體患大腸癌的風險(OR)是攜帶快速基因型箇體的2.16倍(95%C:1.31～3.54).結論 NAT2基因多態性與大腸癌的易感性有關,攜帶慢速基因型的人群患大腸癌的風險增加.
목적 탐토N-을선기전이매-2(NAT2)기인다태성급배경폭로여대장암역감성적관계.방법 이병례대조연구방법,채용취합매련반응.한제성편단장도다태성(PCR-RFLP)기인분형기술,대86대대장암환자화비종류환자(대조조)NAT2기인형진행측정.결과 NAT2 만속기흉형재병례조적빈솔위19.58%(56례),대조조위10.14%(29례),차이구유통계학의의(χ~2 10.07,P:0.00).휴대NAT2만속기인형적개체환대장암적풍험(OR)시휴대쾌속기인형개체적2.16배(95%C:1.31～3.54).결론 NAT2기인다태성여대장암적역감성유관,휴대만속기인형적인군환대장암적풍험증가.
Objective To explore the relationship between NAT2 genetic polymorphism and the risk of colorectal cancer. Methods A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect its genotypes.Results The frequency of NAT2 slow genotype was 19.58% in cases with colorectal cancer compared.with increased the risk for developing colorectal cancer and their OR were 2.16(95% CI:1.31～3.54).Conclusion The results suggest that NAT2 genetic polymorphism is associated with colorectal canoer susceptibility.People with NAT2 slow genotype have higher coloreetal cancer risk.
