中华胸心血管外科杂志
中華胸心血管外科雜誌
중화흉심혈관외과잡지
Chinese Journal of Thoracic and Cardiovascular Surgery
2008年
2期
102-104
,共3页
食管肿瘤%淋巴转移%血管内皮生长因子C
食管腫瘤%淋巴轉移%血管內皮生長因子C
식관종류%림파전이%혈관내피생장인자C
Esophageal neoplasms%Lymphatic metastasis%Vascular endothelial growth factor C
目的 观察血管内皮生长因子C(VEGF-c)在食管癌组织、血清及胸导管淋巴液中的表达,分析其与肿瘤淋巴结转移的关系.方法 应用免疫组织化学SP法检测76例食管癌组织中VEGF-C的表达,酶联免疫吸附(ELISA)法测定血清和胸导管淋巴液中VEGF-C含量.结果 食管癌VEGF-C表达阳性率为63.1%,VEGF-C表达与食管癌的淋巴结转移、TNM分期显著相关(P<0.01,P<0.05),与病人年龄、肿瘤长度及病理类型无关;胸导管淋巴液中VEGF-C含量明显高于血清并与淋巴结转移有显著相关性(P<0.05).结论 食管癌组织中VEGF-C表达与肿瘤TNM分期、淋巴结转移呈明显正相关.胸导管淋巴液中VEGF-C含量明显较血清中高,淋巴液和血清中VEGF-C含量同食管癌淋巴结转移正相关.
目的 觀察血管內皮生長因子C(VEGF-c)在食管癌組織、血清及胸導管淋巴液中的錶達,分析其與腫瘤淋巴結轉移的關繫.方法 應用免疫組織化學SP法檢測76例食管癌組織中VEGF-C的錶達,酶聯免疫吸附(ELISA)法測定血清和胸導管淋巴液中VEGF-C含量.結果 食管癌VEGF-C錶達暘性率為63.1%,VEGF-C錶達與食管癌的淋巴結轉移、TNM分期顯著相關(P<0.01,P<0.05),與病人年齡、腫瘤長度及病理類型無關;胸導管淋巴液中VEGF-C含量明顯高于血清併與淋巴結轉移有顯著相關性(P<0.05).結論 食管癌組織中VEGF-C錶達與腫瘤TNM分期、淋巴結轉移呈明顯正相關.胸導管淋巴液中VEGF-C含量明顯較血清中高,淋巴液和血清中VEGF-C含量同食管癌淋巴結轉移正相關.
목적 관찰혈관내피생장인자C(VEGF-c)재식관암조직、혈청급흉도관림파액중적표체,분석기여종류림파결전이적관계.방법 응용면역조직화학SP법검측76례식관암조직중VEGF-C적표체,매련면역흡부(ELISA)법측정혈청화흉도관림파액중VEGF-C함량.결과 식관암VEGF-C표체양성솔위63.1%,VEGF-C표체여식관암적림파결전이、TNM분기현저상관(P<0.01,P<0.05),여병인년령、종류장도급병리류형무관;흉도관림파액중VEGF-C함량명현고우혈청병여림파결전이유현저상관성(P<0.05).결론 식관암조직중VEGF-C표체여종류TNM분기、림파결전이정명현정상관.흉도관림파액중VEGF-C함량명현교혈청중고,림파액화혈청중VEGF-C함량동식관암림파결전이정상관.
Objective To investigate the expression of vascular endothelial growth factor C(VEGF-C ) in tissue, serum and lymph fluid in esophageal cancer patients, and the relationship between its expression and tumor lymphatic metastasis. Methods Expressions of VEGF-C in 76 cases of ESC was detected by immunohisto-chemical SP method and VEGF-C levels in lymph fluid and serum were assessed by enzyme-linked immunosorbent assay. Results Positive immunostaining of VEGF-C in esophageal cancer tissue was 63.1%,The expression of VEGF-C in tissue was significantly associated with lymph node metastasis and TNM stage ( P<0.01, P<0.05 respectively), but not to patient age, tumor length or differentiation; VEGF-C in lymph fluid is significantly higher than in serum( P<0.05) ; The expression of VEGF-C in lymph fluid end serum were significantly associated with lymph node metastasis( P<0.05). Conclusion There are cliuical significance between VEGF-C expression and lymph node metastasis、TNM stage in tissue of esophageal cancer. The level of VFGF-C in lymph fluid is higher than that in serum, both associate with lymph-node metastasis closely.
