CAJ | 학술논문

背景:国内外研究鱼油对血脂水平的影响报道不一,目前国内有关此方面的研究多以大鼠作为动物模型. 目的:研究膳食鱼油对高脂血症金黄地鼠血脂水平的影响. 设计:随机对照研究. 单位:一所大学教学医院的实验动物中心. 材料:实验于 2001- 06/2001- 12 在南京总医院动物实验中心完成.选择体质量为 70～ 90 g的雄性金黄地鼠 40只(购于上海动物实验中心),随机分为 4组,即对照组, 0.5 mL, 0.8 mL和 1.2 mL鱼油组,每组 10只. 方法:建立高脂血症金黄地鼠动物模型,对照组予以生理盐水 1 mL/d, 0.5 mL, 0.8mL和 1.2 mL鱼油组分别予以不同量鱼油 (0.5 mL/d、 0.8 mL/d和 1.2 mL/d)喂饲,观察其对血脂水平的影响. 结果: 0.8mL鱼油组和 1.2 mL鱼油组三酰甘油水平分别为 [( 3.91 ± 2.32),( 6.22± 3.81) mmol/L], 比对照组 [( 9.02± 3.90) mmol/L]明显降低( t=3.46,P< 0.01和 t=2.65,P< 0.05); 0.8 mL鱼油组三酰甘油水平与 0.5mL鱼油组 [( 8.14± 3.84) mmol/L]相比 , 差异有显著性意义( t=2.92,P< 0.05).各组高密度脂蛋白均未见差异有显著性意义( P >0.05). 结论 :膳食鱼油具有降低血三酰甘油作用,其中以进食中等量鱼油组效果最佳;而未见其具有降低胆固醇及升高高密度脂蛋白的作用.
배경:국내외연구어유대혈지수평적영향보도불일,목전국내유관차방면적연구다이대서작위동물모형. 목적:연구선식어유대고지혈증금황지서혈지수평적영향. 설계:수궤대조연구. 단위:일소대학교학의원적실험동물중심. 재료:실험우 2001- 06/2001- 12 재남경총의원동물실험중심완성.선택체질량위 70～ 90 g적웅성금황지서 40지(구우상해동물실험중심),수궤분위 4조,즉대조조, 0.5 mL, 0.8 mL화 1.2 mL어유조,매조 10지. 방법:건립고지혈증금황지서동물모형,대조조여이생리염수 1 mL/d, 0.5 mL, 0.8mL화 1.2 mL어유조분별여이불동량어유 (0.5 mL/d、 0.8 mL/d화 1.2 mL/d)위사,관찰기대혈지수평적영향. 결과: 0.8mL어유조화 1.2 mL어유조삼선감유수평분별위 [( 3.91 ± 2.32),( 6.22± 3.81) mmol/L], 비대조조 [( 9.02± 3.90) mmol/L]명현강저( t=3.46,P< 0.01화 t=2.65,P< 0.05); 0.8 mL어유조삼선감유수평여 0.5mL어유조 [( 8.14± 3.84) mmol/L]상비 , 차이유현저성의의( t=2.92,P< 0.05).각조고밀도지단백균미견차이유현저성의의( P >0.05). 결론 :선식어유구유강저혈삼선감유작용,기중이진식중등량어유조효과최가;이미견기구유강저담고순급승고고밀도지단백적작용.
BACKGROUND:There are various reports on the effects of fish oil on lipid level at home and abroad.At present,the related researches domestically are carried on mostly taken rats as the animal model. OBJECTIVE:To study the influence of dietetic fish oil on lipid level of golden hamsters with hyperlipemia. DESIGN:A randomized controlled study. SETTING:The experimental animal center of a teaching hospital affiliated to a university. PARTICIPANTS:The experiment was performed in the Experimental Animal Center of Nanjing General Hospital from June to December 2001.Forty male golden hamsters weighing 70 to 90 g(bought from Shanghai Animal Experiment Center) were randomized into 4 groups with 10 in each, named as the control group,0.5 mL fish oil group,0.8 mL fish oil group and 1.2 mL fish oil group. INTERVENTIONS:The golden hamster models of hyperlipemia were established.Golden hamsters in the control group were treated with saline 1 mL per day,while in the 0.5, 0.8 and 1.2 mL fish oil groups, fish oil of various dosages was applied(0.5,0.8 and 1.2 mL per day) successively to observe the effects on lipid level. RESULTS:In the 0.8 and 1.2 mL fish oil groups, the levers of triglyceride(TG) were(3.91± 2.32) and(6.22± 3.81)mmol/L respectively,which were remarkably reduced as compared with that in the control group[(9.02± 3.90) mmol/L](t=3.46,P< 0.01;t=2.65,P< 0.05). The TG level in the 0.8 mL fish oil group was significantly different from that in the 0.5 mL fish oil group[(8.14± 3.84) mmol/L](t=2.92,P < 0.05).The level of cholesterol and high density lipoprotein(HDL) had insignificant differences(P >0.05). CONCLUSION:Dietetic fish oil acts on reducing blood TG,for which, the effect of the moderate dosage is the best. Its effects in reducing cholesterol and increasing HDL are not apparent.