CAJ | 학술논문

健康牙鲆口服剂量为100 mg/kg的甲氧苄氨嘧啶后,利用高效液相色谱测定药物在牙鲆肌肉、血液、肾脏、肝脏质量浓度变化,并通过3P87药动学软件分析数据.试验结果表明,甲氧苄氨嘧啶在肌肉、血液、肾脏、肝脏4种组织中均符合一级吸收二室开放模型,其在上述4种组织中的达峰时间(t_(max))分别为18.72、12.94、23.13 h和19.49 h;达峰质量浓度分别为13.80、18.23、32.79、27.40 μg/ml;消除半衰期分别为23.64、21.47、16.72 h和15.99 h.口服甲氧苄氨嘧啶,在牙鲆体内吸收与消除较慢,血药浓度高,维持时间长.
건강아평구복제량위100 mg/kg적갑양변안밀정후,이용고효액상색보측정약물재아평기육、혈액、신장、간장질량농도변화,병통과3P87약동학연건분석수거.시험결과표명,갑양변안밀정재기육、혈액、신장、간장4충조직중균부합일급흡수이실개방모형,기재상술4충조직중적체봉시간(t_(max))분별위18.72、12.94、23.13 h화19.49 h;체봉질량농도분별위13.80、18.23、32.79、27.40 μg/ml;소제반쇠기분별위23.64、21.47、16.72 h화15.99 h.구복갑양변안밀정,재아평체내흡수여소제교만,혈약농도고,유지시간장.
The trimethoprim(TMP)levels were analyzed in the muscle, blood, kidney and liver of Japanese flounder Paralichthys olivaceus orally administrated by reversed-phase high performance liquid chromatography and 3P87 softward to study the pharmacokinetics of TMP in the fish. The results showed a two-compartment open model best fitted the data in the four tissues. The major pharmacokinetic parameters in muscle, blood, kidney and liver were as follows,respectively:Time when maxium concentration(t_(max)max)was obtained were 18.72 h, 12.94 h, 23.13 h and 19.49 h; maximum concentration(C_(max))were 13.80 μg/ml, 18.23 μg/ml, 32.79 μg/ml and 27.40 μg/ml;elimination half-life(t_((1/2)β))were 23.64 h, 21.47 h, 16.72 h and 15.99 h, indicating that the assimilation and elimination of TMP was slower, that the level in blood was higher and that the maintaining time was longer in Japanese flounder.